Insect Nicotinic Acetylcholine Receptors

ISBN-13: 9781493951536 / Angielski / Miękka / 2016 / 118 str.

Opis

This book investigates insect nicotinic acetylcholine receptors. It explores the involvement of insect nicotinic receptors in learning and memory processes, using the honeybee as insect model. The book a will serves as a useful guide to the field.

The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.

Spis treści

1. Identification of Cholinergic Synaptic Transmission in the Insect Nervous System Steeve Hervé Thany, Hélène Tricoire?Leignel and Bruno Lapied Abstract Introduction Insect Acetylcholinesterase: Catalytic Properties and Tissue Distribution Identification and Tissue Distributions of Choline Acetyltransferase in Insects Identification of Native Neuronal Nicotinic Acetylcholine Receptors Insect Nicotinic Acetylcholine Receptors Subunit Localizations Conclusion 2. The Evolution of Pentameric Ligand?Gated Ion Chanels Joseph A. Dent Abstract Introduction Structure: pLGICs share an underlying structure Function: pLGICs Can Mediate Many Types of Ionotropic Neurotransmission Evolution: pLGIC Diversity Appears To Be Ancient What Good is pLGIC Diversity? 3. Diversity of Insect Nicotinic Acetylcholine Receptor Subunits Andrew K. Jones and David B. Sattelle Abstract Introduction Nicotinic Acetylcholine Receptors (nAChRs)—Structure and Function Nicotinic Acetylcholine Receptors—Roles in Human Disease and as Drug Targets Insect Nicotinic Acetylcholine Receptors—Targets for Pest Control The nAChR Gene Family in a Genetic Model Organism, the Fruitfly Drosophila melanogaster Characterisation of Complete nAChR Gene Families from Five Insect Species Spanning Over 300 Million Years of Evolution RNA Editing and Alternative Splicing Broadens the Insect Nicotinic “Recepterome” Conclusion and Prospects 4. Identification of Critical Elements Determining Toxins and Insecticide Affinity, Ligand Binding Domains and Channel Properties Hélène Tricoire?Leignel and Steeve Hervé Thany Abstract Introduction Toxins—nAChRs Interaction Insecticides—nAChRs Interaction: Residues Involved in Neonicotinoid Selectivity Insecticides—nAChRs Interaction: Residues Involved in Neonicotinoid Binding Amino?Acid Involved in Ionic Selectivity Conclusion 5. Electrophysiological Studies and Pharmacological Properties of Insect Native Nicotinic Acetylcholine Receptors Steeve HervéThany Abstract Introduction Pharmacological Profiles of Native Nicotinic Receptors Associated to Specific Neurons Contribution of ‘Mixed’ Nicotinic/Muscarinic Receptor to the Complexity of Native Nicotinic Receptors Ca2+ and Ca2+ Pathways as Intracellular Regulators of Insect Neuronal Nicotinic Receptors Other Modulators of Insect Native Nicotinic Acetylcholine Receptors Conclusion 6. Characterisation of Insect Nicotinic Acetylcholine Receptors by Heterologous Expression Neil S. Millar and Stuart J. Lansdell Abstract Introduction Characterization of Insect nAChRs by Heterologous Expression Characterization of Hybrid nAChRs Characterization of Chimeric nAChR Subunits Co?Expression of Molecular Chaperones Pharmacological Properties of Recombinant nAChRs Conclusion 7. Neonicotinoid Insecticides: Historical Evolution and Resistance Mechanisms Steeve Hervé Thany Abstract Introduction Nicotine, Nicotinoids and Insecticidal Activities Neonicotinoid Insecticides Development of Novel Neonicotinoid Insecticides Multiple Origins of Insect Resistance to Neonicotinoid Insecticides Conclusion 8. Ecotoxicity of Neonicotinoid Insecticides to Bees Axel Decourtye and James Devillers Abstract Introduction Effects on Survival Behavioral Effects Conclusion 9. State of the Art on Insect Nicotinic Acetylcholine Receptor Function in Learning and Memory Monique Gauthier Abstract Introduction Role of ACh and Nicotinic Acetylcholine Receptors in Insect Behavior Role of Nicotinic Acetylcholine Receptors in Learning and Memory in the Honeybee Conclusion and Outlook: Using RNA Interference to Create Reversible Mutant Honeybees for Memory Index

O autorze

Steeve Hervé Thany is an assistant Professor for Neurobiology and Neurophysiology at the University of Angers, France. Its research interests are in the areas of molecular biology, electrophysiology, pharmacology and behavioral processes involving insect nicotinic acetylcholine receptors. Recent research focused on the effects of neonicotinoid insecticides on nicotinic receptors and the intracellular mechanisms regulating their function. He is a member of numerous national and international scientific organisations, including the French Society for Neuroscience (SN) and the Federation of European Neuroscience Societies (FENS).