Inhaled Medicines: Optimizing Development Through Integration of in Silico, in Vitro and in Vivo Approaches

ISBN-13: 9780128149744 / Angielski / Miękka / 2021

Stavros Kassinos; Per Backman; Joy Conway

Recenzje

"I have never reviewed a book that was entirely dedicated to just one method of drug delivery, so this seems to be a rather complete text. Future technologies are featured, but when they become reality, additional drug exploration will warrant an updated edition. Weighted Numerical Score: 100 - 5 Stars!" --© Doody's Review Service, 2021, Patrick J. McDonnell, reviewer, expert opinion

Spis treści

1. Historical perspective - Disruptive technologies and strategies 2. The API 3. Devices and formulations: General introduction and wet aerosol delivery systems 4. Metered dose inhalers (MDIs) 5. Dry powder inhalers (DPIs) 6. In vitro methods to study dose deposition 7. In silico methods to model dose deposition 8. Non-absorptive clearance from airways 9. Dissolution and drug release 10. Epithelial permeability and drug absorption in the lungs 11. Drug distribution in lung tissue 12. Physiologically-based pharmacokinetic modeling after drug inhalation 13. Inhaled aerosols: Emerging clinical methods 14. Machine learning and in silico methods 15. The emerging state of the art