Informing Clinical Practice in Nephrology: The Role of RCTs

ISBN-13: 9783319348209 / Angielski / Miękka / 2016 / 243 str.

Mohsen El Kossi; Arif Khwaja; Meguid El Nahas

Opis

Historically, clinical decisions in renal medicine have been challenged by the scarce availability of robust supportive evidence. Not only are the number of randomized controlled trials (RCTs) in Nephrology the third lowest amongst the medical specialties but in many instances the trials themselves are of poor quality. In addition, practice has been further influenced by extrapolation from the outcomes of general population clinical trials which exclude renal patients. The difference between the ideal trial participant and real complex cases encountered in daily practice is well recognized and further compounded in renal patients with complex pathophysiology - this ultimately makes decision making in this subset of patients a real challenge. Recently, there has been a growing interest in conducting well designed RCTs in different areas of renal medicine. However, though clinical guidelines are helpful in providing the clinicians with a frame of best available evidence for a clinical condition, it denies the unique nature of each individual patient. This book offers a thorough and critical appraisal and evaluation of the key published clinical trials that have shaped current practice in nephrology, dialysis and transplantation. It will help the practicing physician close the gap between the inflexible and generalized nature of clinical guidelines and the day-to-day clinical decision-making for individual patients. It will provide the clinician with the tools required to investigate and extract the appropriate guidance to apply to individual cases in daily practice. Moreover, it will help improve the ability of junior colleagues to appraise available evidence in a systematic way when there is lack of local guidelines or when the guidelines are difficult to apply due to logistic constraints or barriers. Lastly, this book will serve as a reference for key clinical trials in different areas of renal medicine together with literature and authors views of these trials and their impact on changing practice.​

Recenzje

"This book provides an interesting look at several important trials in the field of nephrology. ... This book will be very useful for students, residents, and fellows learning to critically analyze published trials, but it also will appeal to providers in the field who encounter these clinical situations. ... This will be a great asset for those involved in the care of patients with kidney disease." (Jon Webb, Doody's Book Reviews, April, 2016)

Spis treści

Management of ADPKD.- Secondary Glomerular Disease Lupus Nephritis.- ANCA-Associated Vasculitis.- Acute Kidney Injury.- Chronic Kidney Disease.- Anaemia in Chronic Kidney Disease (CKD).- Lipids and Chronic Kidney Disease.- Chronic Kidney Disease with Mineral and Bone Disorder (CKD-MBD).- Diabetic Nephropathy.- Primary Glomerular Disease.- Hemodialysis.- Peritoneal Dialysis.- Transplantation.

Blurb

This book offers a thorough and critical appraisal and evaluation of the key published clinical trials that have shaped current practice in nephrology, dialysis and transplantation. It will help the practicing physician close the gap between the inflexible and generalized nature of clinical guidelines and the day-to-day clinical decision-making for individual patients. Furthermore, it will provide clinicians with the tools required to investigate and extract the appropriate guidance to apply to individual and often complex cases encountered in daily practice. Lastly, it will improve the ability of junior colleagues to appraise available evidence in a systematic way when there is lack of local guidelines or when the guidelines are difficult to apply due to logistic constraints or barriers.

Informing Clinical Practice in Nephrology: The Role of RCTs is an essential reference text for renal specialists, nephrologists in training, transplant and renal surgeons as well as, researchers in renal medicine, intensivists specializing in acute kidney injury (AKI), immunologists, general practitioners and other clinicians who are interested in chronic kidney disease (CKD).