Influenza Pathogenesis and Control - Volume II

ISBN-13: 9783319379777 / Angielski / Miękka / 2016 / 484 str.

Michael B. a. Oldstone; Richard W. Compans

Opis

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.

Spis treści

Part I: Innate immunity

 

The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options

John R. Teijaro

 

Innate immune sensing and response to influenza 

Mohan S. Maddur and Bali Pulendran

 

The NS1 protein: a multitasking virulence factor 

Juan Ayllon and Adolfo Garcia-Sastre

 

Role of NK cells in influenza infection 

Stacey Shultz-Cherry

 

Host detection and the stealthy phenotype in influenza virus infection

Pradyot Dash and Paul G. Thomas

 

 

Part II: Vaccines and adaptive immunity

 

Inactivated and adjuvanted influenza vaccines

Giuseppe Del Giudice and Rino Rappuoli

 

Live attenuated influenza vaccine

Hong Jin and Kanta Subbarao

 

Design of alternative live attenuated influenza virus vaccines

Courtney Finch, Weizhong Li and Daniel R. Perez

 

Rapid production of synthetic influenza vaccines

Philip R. Dormitzer

 

Influenza neuraminidase as a vaccine antigen

Maryna C. Eichelberger and Hongquan Wan

 

Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin

Florian Krammer, Peter Palese and John Steel

 

Structural characterization of epitopes recognized by broadly cross-reactive antibodies

Peter S. Lee and Ian A. Wilson

 

Skin immunization with influenza vaccines

Ioanna Skountzou and Richard W. Compans

 

Mucosal immunization and adjuvants 

Hideki Hasegawa, Elly van Reit and Hiroshi Kida

 

B cell responses to infection and vaccination

Christopher Chiu, Ali Ellebedy, Jens Wrammert and Rafi Ahmed

 

Memory CD4 T cells in influenza

Kyra D. Zens and Donna L. Farber

 

The effector T cell response to influenza infection

Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale

 

 

Part III: New antiviral discovery

 Antiviral Effects of Inhibiting Host Gene Expression

 Ralph A. Tripp and S. Mark Tompkins

 

O autorze

Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University School of Medicine, Atlanta, GA, USA and series editor and volume editor of several successful volumes of Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a professor at the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA and series editor and volume editor of several successful volumes of Current Topics in Microbiology and Immunology.