Influenza Pathogenesis and Control - Volume I

ISBN-13: 9783319111544 / Angielski / Twarda / 2014 / 444 str.

Richard W. Compans; Michael B. a. Oldstone

Opis

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.

Spis treści

Part I: Molecular determinants of pathogenicity

 The Hemagglutinin - a Determinant of Pathogenicity

Eva Böttcher-Friebertshäuser, Wolfgang Garten, Mikhail Matrosovich, and Hans Dieter Klenk

 Molecular determinants of pathogenicity in the polymerase complex

Gülsah Gabriel and Ervin Fodor

 Part II: Virus entry and cell tropism

 Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range

Xiaoli Xiong, John W. McCauley, David A. Steinhauer

 Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology

Charles J. Russell

Part III: Transmission and Pandemics

 Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT)

Nancy J. Cox, Susan C. Trock and Stephen A. Burke

 Avian influenza virus transmission to mammals

S. Herfst, M. Imai, Y. Kawaoka and R.A.M. Fouchier

 Transmission in the Guinea Pig Model

Anice C. Lowen, Nicole M. Bouvier and John Steel

 Enhancement of influenza virus transmission by gene reassortment

Chengjun Li and Hualan Chen

 Swine and Influenza: A Challenge to One Health Research

Robert E. Kahn, Wenjun Ma and Jürgen A. Richt

 Part IV: Animal models and pathogenesis

 Influenza Pathobiology and Pathogenesis in Avian Species

Monique S. Franҫa and Justin D. Brown

 Molecular determinants of influenza virus pathogenesis in mice

Ram P. Kamal, Jaqueline M. Katz, and Ian A. York

 Mammalian models for the study of H7 virus pathogenesis and transmission

Jessica A. Belser and Terrence M. Tumpey

 Pathogenesis and vaccination of influenza A virus in swine

Daniela S. Rajao, Tavis K. Anderson, Phillip C. Gauger, Amy L. Vincent

 Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis

Amber M. Smith and Jonathan A. McCullers

 

Part V: Evolution, Antigenic Variation

 Evolution and Ecology of Influenza A viruses

Sun-Woo Yoon, Richard J. Webby and Robert G. Webster

 Influenza A virus reassortment

John Steel and Anice C. Lowen

 Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses

Ruben O Donis

O autorze

Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University, School of Medicine, Atlanta, GA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a Professor at the Department of Immunology and Microbial Science at the Scripps Research Institute, La Jolla, CA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology.