Inflammatory Reaction

ISBN-13: 9783642673139 / Angielski / Miękka / 2011 / 298 str.

H. Z. Movat

Opis

The morphological behaviour of leucocytes* leaving the blood has been studied for more than a hundred years and can be described in some detail, but the mechanisms involved are for the most part still unclear. Following an inflammatory stimulus, dy- namic changes occur in small blood vessels near the inflamed site and are followed by margination of leucocytes and by their adherence to the endovascular surface of endo- out of the vessel in the gaps between endothelial thelial cells. The leucocytes migrate cells and move towards the noxious stimulus, directed presumably by chemotactic gra- dients. Having reached the gradient source, they may engage in phagocytosis, killing and digestion of micro-organisms or of damaged tissue. In this review, we deal with the adhesive properties of leucocytes, which have US1,l;ll- ly been measured in vitro, and with their possible relevance to the leucocyte-endo- We also deal with the locomotion of leucocytes, its machinery thelial cell interaction.

Spis treści

Ultrastructure of Acute Inflammation. With 20 Figures.- Hyperemia, Stasis, and Increase in Vascular Permeability: New Methods for Their Quantitation. With 9 Figures.- The Adhesion, Migration and Chemotaxis of Leucocytes in Inflammation. With 5 Figures.- Kinetics of the Inflammatory Response in Regional Lymph. With 13 Figures.- The Kinin System and its Relation to Other Systems. With 9 Figures.- The Complement System and Inflammation. With 11 Figures.- Phagocytic Cells During an Acute Inflammatory Reaction. With 5 Figures.- Phlogistic Substances in Neutrophil Leukocyte Lysosomes: Their Possible Role in Vivo and Their in Vitro Properties. With 11 Figures.- Cellular Hypersensitivity and Inflammation. With 5 Figures.- The Role of Prostaglandins in Inflammation. With 7 Figures.