Inflammatory Processes: Molecular Mechanisms and Therapeutic Opportunities

ISBN-13: 9783764360252 / Angielski / Twarda / 2000 / 200 str.

L.Gordon Letts;Douglas W. Morgan

Opis

In October 1998, key leaders of new drug discovery for inflammatory di seases gathered at Hershey, Pennsylvania, for the 10th International C onference of the Inflammation Research Association. The conference pro vided a stimulating environment for the open exchange of important adv ances in basic inflammation research and new drug discovery and develo pment. This book encompasses highlights of several presentations made at the conference and contains some of the latest and important develo pments in the field of inflammation research.

Spis treści

Contents. List of Contributors. Preface. T.J. Mitchell and T.J.
Williams: The role of eotaxin and related CC-chemokines in asthma and
allergy. Roger J. Davis: Signal transduction by the JNK group of MAP
kinases. Marie Chabot-Fletcher: TNF and IL-1 signaling to NF-kB. Anthony
M. Manning: Small molecule regulators of AP-1 and NF-kB. Robert T.
Abraham: Mammalian target of rapamycin: Immunosuppressive drugs offer
new insights into cell growth regulation. Catherine A. Burton, John
Boylan, Candy Robinson, Janet Kerr and Pamela Benfield: Constitutive
expression of a tumor suppressor leads to tumor regression in a
xenograft model. Steven D. Shapiro: Macrophage metalloproteinases in
destructive inflammatory diseases. Nancy H. Ruddle: Lymphotoxin in
inflammation and lymphoid organ development: Variations on a theme.
Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam and
Stephen W. Chensue: Chemokine/cytokine biology during the evolution of
fibrotic disease. Long Gu, Susan C. Tseng and Barrett J. Rollins: The
role of MCP-1 in disease. Lisa A. Beck, Cristiana Stellato, Syed
Shahabuddin, Renate Nickel and Robert P. Schleimer: The role of
chemokines in allergic diseases of the airways. James Winkler and Ken
Tramposch (coordicators): Ninth International Conference of the
Inflammation Research Association, November 1-5, 1998: Summaries of
workshops and poster discussions. William Williams and Elizabeth Arner
(chair persons): Targets in rheumatoid and osteoarthritis. Lawrence
Wennogle and Nancy Cusack (chair persons): Signal transduction and
regulation of gene expression. James Burke and Floyd Chilton (chair
persons): Mediators in inflammation and their enzymes. Denis Schrier and
Fandrew Issekutz (chair persons): Cell adhesion molecules and leukocyte
trafficking. Robert M. Strieter and David Underwood (chair persons):
Pulmonary inflammation, fibrosis, and disease. W. Hunter and E. Turley
(chair persons): Angiogenesis, wound repair and skin inflammation.
Index.