Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management

ISBN-13: 9781617375606 / Angielski / Miękka / 2010 / 362 str.

Alireza Minagar; J. Steven Alezander

Opis

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Recenzje

From the reviews:

"The objective of this book is to provide the readers with a highly detailed review of the basic principles of neuroinflammation and extensive updates of the latest findings on common neuroinflammatory disorders. ... The treatment principles of the different inflammatory disorders are very well covered and up-to-date. This book can be of interest for the institutional library in order for doctors to look up specific details and treatment principles, and to enter deeply into neuroimmunological basics." (Orvar Eeg-Olofsson, European Journal of Paediatric Neurology, Vol. 11, June, 2007)

Spis treści

Endothelial Cell-Leukocyte Interactions During CNS Inflammation J. Steven Alexander and Alireza Minagar Multiple Sclerosis: A Disease of Miscommunication Between the Immune and Central Nervous Systems? Monica J. Carson, Crystal S. Anglen, and Corinne Ploix Cytokines and Brain: Health and Disease Tammy Kielian and Paul D. Drew Chemokines and Central Nervous System Disorders William J. Karpus Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders Wenche Jy, Lawrence L. Horstman, Joaquin J. Jimenez, Alireza Minagar, and Yeon S. Ahn Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Clinical Management William A. Sheremata Neuroprotective Effects of Interferon-b in Multiple Sclerosis Fabrizio Giuliani, Rana Zabad, and V. Wee Yong Acute Disseminated Encephalomyelitis Sean J. Pittock and Dean M. Wingerchuk Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis Staley A. Brod Neuromyelitis Optica Dean M. Wingerchuk Transverse Myelitis: Clinical Manifestations, Pathogenesis, and Management Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, and Douglas A. Kerr Optic Neuritis: Pathogenesis, Immunology, Diagnosis, and Clinical Management Robert Zivadinov and Rohit Bakshi Central Nervous System Vasculitis: Pathogenesis, Immunology, and Clinical Management Shariq Mumtaz, Marjorie R. Fowler, Eduardo Gonzales-Toledo, and Roger E. Kelley Neurosarcoidosis: Pathogenesis, Immunology, and Clinical Management Dakshinamurty Gullapalli and Lawrence H. Phillips, II Neuropsychiatric SLE: Pathogenesis, Immunology, and Clinical Management Deborah Aleman-Hoey and Robin L. Brey Gene Expression in HIV-Associated Dementia Paul Shapshak, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth, and Toni Kazic Human T-Lymphotropic Virus-Associated Neurological Disorders: Pathogenesis, Immunology, and Clinical Management Michael D. Lairmore, Bindhu Michael, Lee Silverman, and Amrithraj Nair West Nile Virus Infection of the Nervous System: Pathogenesis, Immunology, and Clinical Management Douglas J. Lanska Index

Blurb

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders.
Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.