Inflammation and breast cancer

ISBN-13: 9786204447650 / Angielski / Miękka / 60 str.

Jihene Ayari; Shourouk Haj Ammar

Opis

Breast cancer is the second leading cause of malignancy and the fifth leading cause of cancer death worldwide. Inflammation can contribute to the development and progression of cancer. The aim of this study was to measure circulating cytokines (IL17, IL6, IL22, IL23 and TNF ) and their correlation with breast cancer prognostic factors.Serum IL6 levels were significantly higher in advanced stages (p=0.013), especially in metastatic (p=0.001) and relapsed (p=0.010) patients.High levels of TNF were also significantly associated with advanced stages (III and IV) (p = 0.019) and IL22 with high SBR grade (p = 0.028).IL23 was significantly increased in cases of lymph node involvement (p = 0.042) and in young people under 35 (p = 0.034).Finally, IL17 levels were significantly higher in relapsed patients (p = 0.018)Thus, the analysis of serum levels of inflammatory cytokines can help identify patients with a poor prognosis who could benefit from more intensive treatment.

O autorze

Ayari, JiheneBorn in 1979 in Tunis, Medical studies at the Faculty of Medicine of Tunis, degree in clinical carcinology at the Faculty of Medicine Paris Sud and digestive oncology at the Faculty of Medicine Paris V. Associate Professor in Medical Oncology at the Military Hospital Principal of Instruction of Tunis since 2013. President of the ARCC association.