Inflammation and Oxidative Stress in Neurological Disorders: Effect of Lifestyle, Genes, and Age

ISBN-13: 9783319041100 / Angielski / Twarda / 2014 / 355 str.

Akhlaq A. Farooqui

Opis

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Spis treści

1. The effects of diet, exercise, and sleep on brain metabolism and function.-2. Biochemical Aspects of Neuroinflammation.- 3.Contribution of dietary fat in neuroinflammation.- 4. Contribution of receptors, transcription factors, and genes in the induction of neuroinflammation.- 5. Effect of exercise on neurodegeneration in neurological disorders.- 6. Neurochemical Aspects of Oxidative and Nitrosative Stress.- 7. Contribution of dietary fat in the induction of oxidative stress.- 8. Contribution of dietary carbohydrates in induction of oxidative stress.- 9. Contribution of transcription factors and genes in the induction of oxidative stress.- 10. Effect of exercise on oxidative stress in neurological disorders.- 11. Summary, perspective, and directions for future studies.

Blurb

Consumption of healthy balanced diet (colored and green vegetables, fresh fruits, lean meats, fish, and whole grain) along with moderate exercise (30-45 min/day), and 6-7 hours of sleep results in a healthier blood pressure pattern and low cholesterol levels leading into a reduced risk of obesity related diseases, such as diabetes, and metabolic syndrome. Both these pathological conditions are not only the risk factors for heart disease, but also contribute and promote the risk for stroke, Alzheimer disease, and depression. A healthy lifestyle -- which includes a healthy diet with plenty of fruits and vegetables, moderate exercise for maintaining a healthy body weight, and optimal sleep may help in preventing not only diabetes, and metabolic syndrome, but delaying the pathogenesis of stroke, Alzheimer disease, and depression. Information on diet, exercise, and sleep is scattered throughout the literature in the form of original papers, reviews, and some books, which deal with the effects of diet, exercise, and sleep on viscera. This monograph is the first to describe the effect of neuroinflammation and oxidative stress in relation to diet, exercise, and sleep on brain. It describes the contribution of dietary carbohydrates, fats, protein, and nucleic acids in neuroinflammation and oxidative stress in the normal aged brain and in the brains of patients with neurological disorders.  

Inflammation and Oxidative Stress in the Brain presents readers with cutting edge and comprehensive information on the effect of diet, exercise, and sleep on neuroinflammation and oxidative stress in normal brains and brains from patients with neurological disorders. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, nutritionists, exercise physiologists, and physicians, who are curious about the molecular mechanisms that link neuroinflammation and oxidative stress with the pathogenesis of neurotraumatic, neurodegenerative, and neuropsychiatric disorders.