Inflammation and Metastasis » książka
Inflammation and Metastasis
ISBN-13: 9784431567561 / Angielski / Miękka / 2018 / 505 str.
This book provides the latestinformation on cancer metastasis from the standpoint of inflammation,especially innate immune reactions caused by endogenous mediators but notexogenous pathogens, with ideas on how to understand the complicated mechanismsof metastasis as well as to interpret therapeutic targets. The book includesthe topic of the emerging roles of endogenous TLR4 ligands whose functions areshared intriguingly by metastasis and auto-inflammatory diseases such asrheumatoid arthritis. For example, most cancer therapies established so far areeffective initially. However, they eventually face the great obstacles of drugresistance, immune evasion, and metastatic progression. One of the endogenousTLR4 ligands is thought to contribute to all three processes. The mostimportant features of the book are to explain a concept of homeostaticinflammation, disturbance of which in the lungs gives rise to the establishmentof a pre-metastatic pulmonary microenvironment based on primary tumor-mediatedhijacking of the innate immune defense system against respiratory infection. Inaddition, structure-based thinking is another important feature of this book.It is proposed that inflammation forms a functional triangle with angiogenesisand coagulation, in the center of which cancer is located.Given the proposal of precision medicineby President Obama in the United States in 2015 and the recent success ofimmune-modulator-based therapy, this book will appeal to researchers in avariety of fields with the title of the book connecting the worst disease(metastasis) and the most fundamental event (inflammation) that is common tomany diseases.
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