Inflammation and Epilepsy: New Vistas

ISBN-13: 9783030674021 / Angielski / Twarda / 2021 / 237 str.

Damir Janigro; Astrid Nehlig; Nicola Marchi

Spis treści

Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium.- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders.- Glial Mechanisms of Inflammation during Seizures.- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy.- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions.- Autoantibodies, Encephalopathies and Epilepsy.- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline.- Ketogenic Diet, Inflammation and Epilepsy.- Role of Regulatory T cells in Epilepsy.- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.

O autorze

Damir Janigro

Department of Physiology and Biophysics

Case Western Reserve University

Cleveland

Ohio

USA

 

Astrid Nehlig

INSERM

Strasbourg

France

    

Nicola Marchi

Cerebrovascular and Glia Research, Department of Neuroscience

Institute of Functional Genomics

Montpellier,

France

Blurb

This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.