Induction of experimental liver diseases

ISBN-13: 9783659971204 / Angielski / Miękka / 2016 / 84 str.

Jihan Hussein; Mona Anwar El-Banna; Safaa Metwally Morsy

Opis

Liver disorders lead to various pathological changes like fatty liver, increase in ROS or oxidative stress, necrosis of liver cells, hepatitis,steatosis, cholestasis, vascular lesions, and granuloma andveno-occlusive diseases, increase in the level of inflammatory markers, hepatocellular carcinoma which further produce portal hypertension and hepatic failure. Animal models serve as an important tool to identifying the cause of liver injury, pathogenesis. In this project, We highlighted on some chemicals-induced experimental liver diseases. From these using chemicals: Heavy metal , -Carbon tetrachloride , Alcohol, -paracetamol , D-Galactosamine hydrochloride (DGa1N) and lipopolysaccharide (LPS). DGa1N and LPS together give us an experimental model of liver hepatitis that much like viral hepatitis in humans from both morphological and functional points of view.

O autorze

Prof.Jihan Seid Hussein,Professor of Medical Biochemistry,National Research Centre(NRC),Egypt. Member of several international scientific societies, awarded a scientific encouragement prize in Biotechnology of NRC in 2011. Holds a Scientific Excellence Award for the years 2009, 2010, 2011,2012, 2013 and 2014.Reviewer in many international journals.