Induction of Bone Formation in Primates: The Transforming Growth Factor-Beta 3

ISBN-13: 9780367377403 / Angielski / Miękka / 2019 / 212 str.

Ugo Ripamonti

Opis

The product of 20 years of study, this book sums up editor Ugo Ripamonti’s research into the osteogenic activity of the TGF-β growth factor family, particularly in primates. It explores how the three mammalian TGF-β isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book contributes to the fascinating history of BMP and TGF-β research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

Spis treści

Introduction: The Discovery of Redundancy and the Bone Induction Prerogative of the Three Mammalian Transforming Growth Factor-β Isoforms. Regenerative Medicine, the Induction of Bone Formation, Bone Tissue Engineering, and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family. Rapid Induction of Bone Formation by the Transforming Growth Factor-β₃ Isoform. Induction of Bone Formation by the Mammalian Transforming Growth Factor-βs: Molecular and Morphological Insights. Regeneration of Mandibular Defects in Nonhuman Primates by the Transforming Growth Factor-β₃ and Translational Research in Clinical Contexts. Synergistic Induction of Bone Formation by Relatively Low Doses of Transforming Growth Factor-β₁ and -β₃ in Binary Application with Recombinant Human Osteogenic Protein-1. Induction of Periodontal Tissue Regeneration by Recombinant Human Transforming Growth Factor-β₃ with and without Myoblastic/Pericytic Stem Cells in Papio ursinus.

O autorze

Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.