Improving the Therapeutic Ratio in Head and Neck Cancer: Volume 6

ISBN-13: 9780128178683 / Angielski / Twarda / 2019 / 376 str.

Randall J. Kimple

Spis treści

1. Overview of head and neck cancer management2. The role of immunotherapy and molecularly targeted therapies in head and neck cancer3. Targeting the PI3K/mTOR pathway4. Autophagy inhibition to sensitize HNC to radiation and chemotherapy5. Overcoming head and neck cancer stem cells6. TAM Family proteins and therapy resistance7. Eph/Ephrin family proteins and theapy resistance8. Metabolic reprogramming to modulate therapeutic sensitivity9. FGFR and cMET10. Targeting GPCRs in HNC11. Improving the response to immunotherapy12. Chk1/2 inhibition in radiation and cetuximab resistance

O autorze

Benjamin Bonavida, PhD, has been involved in the field of immunology and cancer biology for several decades and has published extensively in the fields of cancer resistance, chemotherapy, immunotherapy, and various molecular approaches to circumvent the resistance of the cancer cells using sensitizing agents. Accordingly, he was the first to publish a book on tumor sensitization in 2008. More recently, Dr. Bonavida is the Series Editor of 3 series published by Elsevier/Academic Press ("Cancer Sensitizing Agents for Chemotherapy,” "Breaking Cancer Resistance to Therapeutic Antibodies,” and "Breaking Tolerance to Anti-Cancer Immunotherapy”) and several books have been published and many are in development. He has published extensively in the field of NK biology and cytotoxicity in the past, and many of these publications were in collaboration with the co-editor Dr. Anahid Jewett. Dr. Kimple completed his MD, PhD in Pharmacology, and residency in Radiation Oncology at the University of North Carolina. He is an Associate Professor of Human Oncology at the University of Wisconsin School of Medicine and Public Health where he is a member of the Multidisciplinary Head and Neck Program and the Wisconsin Head and Neck Cancer SPORE Grant. He runs a translational research lab focused on understanding the molecular basis of therapeutic resistance in head and neck cancer.