Immunotoxicity of Metals and Immunotoxicology

ISBN-13: 9781468484458 / Angielski / Miękka / 2012 / 330 str.

Anthony Dayan; R. F. Hertel; E. Heseltine

Opis

Considerable scientific and political interest has been expressed, parallelling public concern about the effects of chemicals on the immune system and the implications of those effects for health. Coupled with speculation about the magnitude and extent of the problem is discussion of needs for predictive testing and regulatory control measures. The first international seminar on the immunological system as a target for toxic damage was held in Luxembourg in 1984. It was organized by the International Programme on Chemical Safety (United Nations Environment Programme-International Labour Office- World Health Organization) and the Commission of the European Communities with the support of the US Environmental Protection Agency and the National Institute of Environmental Health Sciences (USA) and the participation of the International Society of Immunopharmacology. In view of the perceived importance of imrnunotoxicity, it was considered necessary to organize a follow-up meeting. Thus, an international workshop on the immunotoxicity of metals and immuno- toxicology was held in Hanover, Federal Republic of Germany, on 6-10 November 1989.

Spis treści

Immunotoxicity of metals and immunotoxicology.- The Immune System and Immunotoxicology.- The immune system: an integrated overview.- Concepts and definitions in immunotoxicology.- Immunogenetics.- Dose-effects and dose-responses in immunotoxicology: problems and conceptual considerations.- Recognition of metals by proteins.- Hypersensitivity.- Hypersensitivity: clinical aspects.- Animal models for predicting hypersensitivity reactions to small molecules.- Contact allergy to chromium and nickel.- Allergenic potential of platinum compounds.- Autoimmunity.- Role of cytokines in the induction of autoimmunity.- Immunologically mediated manifestations of metals.- Tests for predicting sensitization to chemicals and their metabolites, with special reference to heavy metals.- Immunotoxicity of Metals.- Immunological and immune-mediated toxic effects of gold compounds used in the treatment of rheumatoid arthritis.- Toxicology of inorganic mercury.- Immunotoxicology of cobalt and selenium.- Immunological diagnosis of chronic beryllium disease in humans and animals.- Effect of organotin compounds on lymphoid organs and lymphoid functions: an overview.- Immunotoxicity of lead, cadmium and arsenic: experimental data and their relevance to man.- Immunotoxicology of lead.- Adverse effects of zinc on the immune system.- Investigations of Immunotoxicity.- Immunotoxicology: functional changes.- The immune system as a target for toxicity: a tiered approach to testing, with special emphasis on histopathology.- Investigative methods: classical techniques.- Reduced immunocompetence and relationships to histopathology of the lymphoid system.- The Immune System: Human Studies.- Clinical aspects of potential innnunotoxic effects of chemicals: diagnosis and epidemiological caution.- Long-term monitoring of human populations for effects on components of the immune system.- Relevance of atopy to the immunotoxic effects of metals.- List of participants.