Immunotherapy of Cancer: Methods and Protocols

ISBN-13: 9781607617853 / Angielski / Twarda / 2010 / 356 str.

Yotnda;¬Abar

Opis

A continuously evolving technique, immunotherapy for the treatment of cancers now incorporates the use of immune cells infused during bone marrow transplants as well as approaches like cell and gene therapy, while stem cell-based therapies, tissue engineering, and targeting have also contributed to the latest successes in pre-clinical immunotherapy studies. In Immunotherapy of Cancer: Methods and Protocols, expert researchers in the field describe detailed procedures for trainees and experts in the area of basic, clinical science who wish to undertake their own cutting-edge immunotherapy studies. In addition to the protocols, the volume also contains two general overviews providing useful updates in each area as well as summaries of recent pre-clinical and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Immunotherapy of Cancer: Methods and Protocols seeks to guide scientists along the path to a further developed system of immunotherapeutic treatments in order to reduce and hopefully eradicate this terrible disease.

Recenzje

From the reviews:

"17 chapters devoted to techniques and their application to the treatment of cancer as well as two general overviews. ... Both trainees and experts in basic and clinical science who wish to undertake studies involving immunotherapy are the intended audience. It would be useful for those who are not familiar with what immunotherapeutic procedures actually involve. ... The book is well put together and offers a lot of information that would be helpful to someone about to embark on developing immunotherapeutic treatments for cancer." (Marion C. Cohen, Doody's Review Service, March, 2011)

Spis treści

1. Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy Patricia Yotnda, Danli Wu, and Anna May Swanson 2. Characterization of Regulatory T Cells in Tumor Suppressive Microenvironments Guangyong Peng 3. Generation of Cytotoxic T Lymphocytes for Immunotherapy of EBV-Associated Malignancies Corey Smith and Rajiv Khanna 4. Acquisition, Preparation, and Functional Assessment of Human NK Cells for Adoptive Immunotherapy Dean A. Lee, Michael R. Verneris, and Dario Campana 5. Enhanced Migration of Human Dendritic Cells Expressing Inducible CD40 Natalia Lapteva 6. Differentiation of Human Embryonic Stem Cells into Hematopoietic Cells in vitro Eun-Mi Kim and Nicholas Zavazava 7. Gene Therapy to Improve Migration of T Cells to the Tumor Site Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo 8. Gene Therapy to Improve Function of T Cells for Adoptive Immunotherapy Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti 9. Cytokine-FC Fusion Genes as Molecular Adjuvants for DNA Vaccines Daniel Hirschhorn-Cymerman and Miguel-Angel Perales 10. Pharmacology of Anti-CD3 Diphtheria Immunotoxin in CD3 Positive T Cell Lymphoma Trials Yu-Jen Lee, Jung Hee Woo, David M. Neville, and Arthur E. Frankel 11. Construction of Human Antibody Gene Libraries and Selection of Antibodies by Phage Display Thomas Schirrmann and Michael Hust 12. Identification of Immunogenic Peptides of the Self-Tumor Antigen: Our Experience with Telomerase Reverse Transcriptase Xochitl Cortez-Gonzalez and Maurizio Zanetti 13. Rescue, Amplification, Purification, and PEGylation of Replication Defective First-Generation Adenoviral Vectors Michael A. Barry, Eric A. Weaver, and S.E. Hofherr 14. Adenovirus-Mediated Interleukin (IL)-24 Immunotherapy for Cancer Rajagopal Ramesh, Constantine G. Ioannides, Jack A. Roth, and Sunil Chada 15. Liposomes for Gene Transfer in Cancer Therapy Nancy Smyth Templeton 16. Oncolytic HSV as a Vector in Cancer Immunotherapy Hongtao Li and Xiaoliu Zhang 17. Generation of Chimeric T Cell Receptor Transgenes and Their Efficient Transfer in Primary Mouse T Lymphocytes Linda J. Berry, Nicole M. Haynes, and Phillip K. Darcy 18. Multi-Walled Carbon Nanotube (MWCNT) Synthesis, Preparation, Labeling, and Functionalization Babak Kateb, Vicky Yamamoto, Darya Alizadeh, Leying Zhang, Harish M. Manohara, Michael J. Bronikowski, and Behnam Badie 19. Cellular Immunotherapy of Cancer Fatma Okur and Malcolm K. Brenner