Immunotherapy and Biomarkers in Neurodegenerative Disorders

ISBN-13: 9781493935581 / Angielski / Twarda / 2016 / 289 str.

Martin Ingelsson; Lars Lannfelt

Opis

This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer s disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson s disease and Huntington s disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab. Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases."

Spis treści

Part I: Immunotherapy Against Amyloid-b in Alzheimer’s Disease

 

1. Immunotherapy Against Amyloid-β in Alzheimer’s Disease: An Overview

            Niels D. Prins

 

2. Active Immunization Against the Amyloid-β Peptide

            Enchi Liu and J. Michael Ryan

 

3. Immunotherapy Against N-Truncated Amyloid-β Oligomers

            Thomas A. Bayer and Oliver Wirths

 

4. Immunotherapy Against Amyloid-β Protofibrils: Opportunities and Challenges

            Lars Lannfelt

 

Part II: Immunotherapy in Other Neurodegenerative Disorders

 

5. Immunotherapy Against α-Synuclein Pathology

            Elvira Valera and Eliezer Masliah

 

6. Extracellular α-Synuclein as a Target for Immunotherapy

            Jun Sung Lee and Seung-Jae Lee

 

7. Immunotherapy of Parkinson’s Disease

            Achim Schneeberger, Suzanne Hendrix, and Markus Mandler

 

8. Tau Immunotherapy

            Einar M. Sigurdsson

 

9. Active and Passive Immunotherapy Against Tau: Effects and Potential Mechanisms

            Kiran Yanamandra, Marc I. Diamond, and David M. Holtzman

 

10. Immunotherapy on Experimental Models for Huntington’s Disease

            Anne Messer

 

Part III: Biomarkers for Neurodegenerative Disorders

 

11. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

            Henrik Zetterberg and Jonathan M. Schott

 

12. Volumetric MRI as a Diagnostic Tool in Alzheimer's Disease

            Eric Westman, Lena Cavalin, and Lars-Olof Wahlund

 

13. PET Imaging as a Diagnostic Tool in Alzheimer´s Disease

            Juha O. Rinne

 

14. Αlpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Disease

            Joakim Bergström and Martin Ingelsson

 

15. Imaging as a Diagnostic Tool in Parkinson’s Disease

            Johan Wikström and Torsten Danfors

 

16. Mass Spectrometry-Based Proteomics in Biomarker Discovery for Neurodegenerative Diseases

            Sravani Musunuri, Ganna Shevchenko, and Jonas Bergquist