Immunology and Immunopathogenesis of Malaria

ISBN-13: 9783642421846 / Angielski / Miękka / 2014 / 234 str.

Jean Langhorne

Opis

Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines. This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.

Spis treści

Preface.- The dissection of CD8 T cells during liver-stage infection.- Early interactions between blood-stage plasmodium parasites and the immune system.- Longevity of the immune response and memory to blood-stage malaria.- Experimental models of cerebral malaria.- Glycosylphosphaditidylinositols in malaria pathogenesis and immunity; potential for therapeutic intervention.- The immunology and pathogenesis of malaria during pregnancy.- Subject index

O autorze

Malaria is still a major killer, taking more than 1 million people yearly. The burden falls heavily on Sub-Saharan Africa, where over 90% of malaria deaths are thought to occur. The toll is rising; malaria-specific mortality in young African children may have doubled during the last twenty years, perhaps due to drug resistance, insecticide resistant mosquitoes, poverty, political upheaval, and lack of effective vaccines. Almost all of these deaths are caused by one species of malaria parasites. This book addresses vital issues of malarial immunity and immunopathology, and will interest not only malariologists, but the broader immunological community.