Immunological Aspects of Viral Oncolysis

ISBN-13: 9783642870460 / Angielski / Miękka / 2012 / 86 str.

Jean Lindenmann; Paul A. Klein

Opis

mouse tissue alloantigen detected by this procedure. An antigen of cross-reacting specificity was revealed in tissue extracts of many other animal species. We next wanted to learn more about the antigen responsible for induction of postoncolytic immunity. Extracts from virus-infected tumors were immunogenic, and both active and inactive fractions of such extracts were obtained. The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one. We consider none of the questions which our work has raised as definitely solved. In fact, we are still working on many of the aspects alluded to above. When we embarked on a study of postoncolytic immunity, we were supported in this endeavor by our lack of experience in the fields of transplantation and tumor immunology.

Spis treści

I. Tumor Immunity. A Brief Review.- Tumor Immunity of the Allograft Type.- Tumor Immunity of the Tumor Specific Type.- II. Viral Oncolysis: A Brief Review.- The Problem of Host Survival.- III. Natural Resistance of Mice to Various Viruses.- Arbo B.- Mouse Hepatitis.- Ectromelia.- Polyoma Virus.- Leukemia Viruses.- Myxoviruses.- Genetics.- Mechanism.- IV. Tumor Immunity following Viral Oncolysis.- 1. The System.- a) Growth of Nonspecific Tumors in A2G Mice.- b) The Oncolytic Virus.- c) Growth of WSA in EA Tumor and Oncolysis.- 2. The Immunity Induced by Oncolysis.- a) Nature of the Immunity.- b) Properties of the Protective Factor.- c) The ?-Alloantigen.- d) Cross Protection Between Nonspecific Tumors.- e) Passive Protection of Syngeneic and Allogeneic Mice with A2G Immune Serum.- f) Immunogenicity of Viral Oncolysates.- g) Tumor Immunity Following Reovirus Oncolysis.- h) Induction of Tumor Immunity Without Viral Oncolysis.- V. General Discussion.- Adjuvant Effect of the Virus.- Status of the Antigens Uncovered by Viral Oncolysis.- Mechanism of Postoncolytic Immunity.- Possible Human Applications.- Summary.- References.