Immunological Approaches to the Diagnosis and Therapy of Breast Cancer

ISBN-13: 9781461290599 / Angielski / Miękka / 2011 / 282 str.

G. P. Talwar

Opis

Once again we have gathered to discover and evaluate advances made in our ability to understand. diagnose and possibly treat breast cancer with the new reagents provided by monoclonal antibody techniques. In the last two years since our first International Workshop on Monoclonal Antibodies and Breast Cancer there has been an enormous surge in the number and quality of applications for these new reagents. Solid achievements have been made in identification and quantitation of estrogen and progesterone receptors. in histopathological diagnostic procedures. in serum diagnosis. and we are witnessing now the first attempts to treat breast cancer with immunoconjugates. Cytosolic estrogen receptors can now be quantitated with monoclonal antibodies. and also their cellular distribution can be directly assessed histologically. In addition. monoclonal antibodies to progesterone receptors have been generated that show promise in having similar uses as those to the estrogen receptor. In the field of diagnosis. the use of monoclonal antibodies has permitted the development of serological approaches for early diagnosis by identifying and measuring breast epithelial antigens in serum. and of histological approaches for establishing criteria for breast cancer dissemination and prognosis. With great expectations we are all following developments in the area of breast cancer treatment using conjugates of anti-breast epithelial monoclonal antibodies which are now confirming earlier reports in affecting breast tumor control. The recent creation of newer monoclonal antibodies and conjugates await experimentation and clinical trials to determine their value.

Spis treści

Sessions I and II.- Characterization of Cross-Related Antigens of Human Milk Fat Globule Membrane and Breast Tumors Detected By A New Monoclonal Antibody Panel.- A Multiparametric Study by Monoclonal Antibodies in Breast Cancer.- Molecular and Immunological Analysis of Mucin Molecules Produced by Normal and Malignant Human Mammary Epithelial Cells.- Single Cell Heterogeneity in Breast Cancer.- Monoclonal Antibody Studies of Drug Resistance.- The Use of Multitumor/Tissue (Sausage) Blocks for Immunohistologic Screening of Monoclonal Antibodies.- Advances Towards Clinical Relevance of Breast Carcinoma Associated Antigens.- Session III.- Detection and Assay of the 52K Estrogen-Regulated Protease in Mammary Tumors.- Diversity of Antigenic Expression on Normal and Malignant Human Mammary Cells Recognized By A New Panel of Monoclonal Antibodies.- Immunochemical Evaluation of Estrogen Receptor and Progesterone Receptor in Breast Cancer.- Application of Monoclonal Antibodies Against Estrogen and Progesterone Receptors in the Immunocytochemical Evaluation of Breast Carcinomas.- Heterogeneity vs. Asynchrony of Receptor Expression in Breast Cancer as Determined by Monoclonal Antibodies.- Immunoaffinity Purification and Structural Analysis of Human Breast Cancer Progesterone Receptors.- Session IV.- Analysis of the Humoral Immune Repertoire in Patients with Cancer.- An Improved Method for the Radiohalogenation of Monoclonal Antibodies.- Studies on a Epithelial/Epithelial Malignancy Associated Antigen Associated with Human Adenocarcinomas.- A Serum Test for the Diagnosis and Monitoring the Progress of Breast Cancer.- Experimental Therapy of Breast Cancer with Anti-breast Epithelial Radioimmunoconjugates.- Antibody Guided Diagnosis and Therapy of Patients With Breast Cancer.- Contributors.