Immunoinformatics

ISBN-13: 9781493911141 / Angielski / Twarda / 2014 / 586 str.

Rajat K. De; Namrata Tomar

Opis

At the intersection of experimental and computational sciences, the second edition of Immunoinformatics provides biological insights as well as a simpler way to implement approaches and algorithms in the immunoinformatics research domain. After an introductory section, this extensive volume moves on to cover topics such as databases, tools for prediction, systems biology approaches, as well as a variety of immunoinformatics applications. As part of the highly successful Methods in Molecular Biology series, chapters include the type of detailed information and implementation advice to ensure successful results.Comprehensive and practical, Immunoinformatics, Second Edition aims at students and researchers from diverse backgrounds and levels interested in working with immunological problems.

Spis treści

Part I: Immunoinformatics: Transition from Basic Biology to Informatics

 

1. A Brief Outline of the Immune System

            Namrata Tomar and Rajat K. De

 

2. Crosstalk Between the Metabolic and Immune Systems

            Namrata Tomar and Rajat K. De

 

3. Immunoinformatics: A Brief Review

            Namrata Tomar and Rajat K. De

 

Part II: Databases

 

4. Immunoinformatics of the V, C and G Domains: IMGT® Definitive System for IG, TR and IgSF, MH and MhSF

            Marie-Paule Lefranc

 

5. IMGT/HLA and the Immuno Polymorphism Database

            James Robinson, Jason A. Halliwell, and Steven G.E. Marsh

 

6. Databases for T-Cell Epitopes

            Chun-Wei Tung

 

7. Databases for B-Cell Epitopes

            Juan Liu and Wen Zhang

 

8. Antigen-Antibody Interaction Database (AgAbDb): A Compendium of Antigen-Antibody Interactions

            Urmila Kulkarni-Kale, Snehal Raskar-Renuse, Girija Natekar-Kalantre, and Smita A. Saxena

 

9. Allergen Databases

            Gaurab Sircar, Debasree Sarkar, Swati Gupta Bhattacharya, and Sudipto Saha

 

Part III: Tools for Prediction

 

10. Prediction of Conformational B-Cell Epitopes

            Wen Zhang, Yanqing Niu, Yi Xiong, and Meng Ke

 

11. Computational Prediction of B Cell Epitopes from Antigen Sequences

            Jianzhao Gao and Lukasz Kurgan

 

12. Machine Learning Based Methods for Prediction of Linear B-Cell Epitopes

            Hsin-Wei Wang and Tun-Wen Pai

 

13. Mimotope-Based Prediction of B-Cell Epitopes

            Jian Huang and Peng Zhou

 

14. Hybrid Methods for B-Cell Epitope Prediction: Approaches to the Development and Utilization of Computational Tools for Practical Applications

            Salvador Eugenio C. Caoili

 

15. Building Hybrid Classifiers for B-Cell Epitopes Prediction

            Yasser EL-Manzalawy and Vasant Honavar

 

16. Multiplex Peptide-Based B-Cell Epitope Mapping

            Sanne M.M. Hensen, Merel Derksen, and Ger J.M. Pruijn

 

17. Classification of Human Leukocyte Antigen (HLA) Supertypes

            Mingjun Wang and Mogens H. Claesson

 

18. Customized Predictions of Peptide-MHC Binding and T-Cell Epitopes Using EPIMHC

            Magdalena Molero-Abraham, Esther M. Lafuente, and Pedro Reche

 

19. T-Cell Epitope Prediction Methods: An Overview

            Dattatraya V. Desai and Urmila Kulkarni-Kale

 

20. Computational Antigenic Epitope Prediction by Calculating Electrostatic Desolvation Penalties of Protein Surfaces

            Sébastien Fiorucci and Martin Zacharias

 

21. In Silico Prediction of Allergenic Proteins

            Gaurab Sircar, Bodhisattwa Saha, Swati Gupta Bhattacharya, and Sudipto Saha

 

22. Prediction of Virulence Factors Using Bioinformatics Approaches

            Rupanjali Chaudhuri and Srinivasan Ramachandran

 

Part IV: Systems Biology Approaches in Immunoinformatics

 

23. A Systems Biology Approach to Study Systemic Inflammation

            Bor-Sen Chen and Chia-Chou Wu

 

24. Procedures for Mucosal Immunization and Analyses of Cellular Immune Response to Candidate HIV Vaccines in Murine and Nonhuman Primate Models

            Shailbala Singh, Pramod Nehete, Patrick Hanley, Bharti Nehete, Guojun Yang, Hong He, Scott M. Anthony, Kimberly Schluns, and K. Jagannadha Sastry

 

25. Immunoinformatics and Systems Biology in Personalized Medicine

            Guillermo Lopez-Campos, Jesús F. Bermejo-Martin, Raquel Almansa, and Fernando Martin-Sanchez

 

Part V: Applications of Immunoinformatics

 

26. The Role of Small RNAs in Vaccination

            Ajeet Chaudhary and Sunil Kumar Mukherjee

 

27. Structure-Based Clustering of Major Histocompatibility Complex (MHC) Proteins for Broad-Based T-Cell Vaccine Design

            Joo Chuan Tong, Tin Wee Tan, and Shoba Ranganathan

 

28. Immunoinformatics, Molecular Modeling, and Cancer Vaccines

            Seema Mishra and Subrata Sinha

 

29. Investigating Host Pathogen Behavior and Their Interaction Using Genome-Scale Metabolic Network Models

            Priyanka P. Sadhukhan and Anu Raghunathan

 

30. Mathematical Models of HIV Replication and Pathogenesis

            Dominik Wodarz