Immunization Against Alzheimer's Disease and Other Neurodegenerative Disorders

ISBN-13: 9783642639371 / Angielski / Miękka / 2011 / 130 str.

Dennis J. Selkoe

Opis

Promising effects in mice of immunization by ss-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises."

Spis treści

Preface.-Immunologic and Tolerogenic Aspects of Amyloid Beta-Peptide: Implications for the Pathogenesis and Treatment of Alzheimer’s Disease.-Towards Diagnosis and Treatment of Alzheimer’s Disease.-Characterization of Amyloid Beta Vaccination Strategies in Mice.-Cognitive Characteristics of TG(APP)CRND8 Mice Immunised With Beta Amyloid Peptide.-Intranasal AßVaccination as an Approach to Treating ß-Amyloidosis.-Improvements in Intranasal Amyloid-ß (Aß) Immunization in Mice.-Antibody Therapy Against ß-Amyloid to Treat Alzheimer’s Disease.-Effects of a Peripheral Anti-Aß Antibody on Plasma and CNS Aß Clearance.-Multiphoton Microscopy: Imaging Plaques and Reversal of Plaques – a Transgenic Model by Multiphoton Microscopy.-Antibodies as Therapeutic Agents for Prion Disease.-Subject Index