Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions

ISBN-13: 9783319186023 / Angielski / Twarda / 2015 / 242 str.

John D. Lambris; Kristina Nilsson Ekdahl; Daniel Ricklin

Opis

​The collection of chapters in this proceedings volume brings together research from academic and industry scientists and clinical development experts who are focused on contemporary and emerging aspects of improving treatments employing biosurfaces. Interactions between biomaterial implants, devices, cell therapies, and whole organ transplants frequently trigger activation of body defense systems and responses that negatively affect the clinical outcome. Optimal tissue integration and modulation of foreign body reactions is therefore essential for preserving anticipated functions and avoiding adverse effects. Topics covered include mechanistic and applied research within the fields of extracorporeal devices, soft and hard tissue implants, tissue and biomaterial-targeting, therapeutic modulation of foreign body reactions, cell encapsulations, as well as cell and whole organ transplantation.

Spis treści

Part 1. Mechanisms.- Thromboinflammation in Therapeutic Medicine.- Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions.- Role of Complement on Broken Surfaces after Trauma.- Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches.- Part 2. Biomaterials.- The Lectin Pathway of Complement and Biocompatibility.- Foreign Body Reaction to Subcutaneous Implants.- Molecular Characterization of Macrophage-Biomaterial Interactions.- Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues.- Part 3. Transplantation.- Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127.- Macro encapsulated Pig Islets Correct Induced Diabetes in Primates up to 6 Months.- Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation—Points for Therapeutic Interventions.- Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy.- Complement Interception Across Humoral Incompatibility in Solid Organ Transplantation–A Clinical Perspective.