Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies

ISBN-13: 9781468447620 / Angielski / Miękka / 2012 / 488 str.

David T. Purtilo; David T. Purtilo

Opis

The discoveries of Burkitt, Epstein, and Henle have laid the foundation for continuing generation of information regarding the mechanisms of induction of diseases by Epstein-Barr virus. The discovery of the virus two decades ago resulted from clinical and basic science collaborative studies on Burkitt lymphoma. Subse quently, nasopharyngeal carcinoma and infectious mononucleosis have been linked etiologically with the virus. During the first decade of research following the discovery of the virus, the mechanisms for the induction of BL, NPC, and IM were sought. At that time one prevailing view was that individual oncogenic strains of EBV were responsible for the different disorders. Paralleling the development of immunology in the 1970's was the accrual of knowledge about immunological events occurring during IM. These studies suggest that immune defense mechanisms deter mine the outcome of this viral infection rather than different viral strains. During the early 1970's, Starzl and Penn and Gatti and Good had noted an increased frequency of malignancy in renal allograft recipients and children with primary immune deficiency disorders, respectively. These observations provoked investigators to restudy the role of immune surveillance against malignancy. At that time immune surveillance was thought to occur against tumor-specific antigens; thereby neoplasms were eliminated."

Spis treści

Immune Deficiency, Epstein-Barr Virus (EBV) and Lymphoproliferative Disorders.- Classical Epstein-Barr Virus Associated Disorders.- Infectious Mononucleosis and Complications.- Nasopharyngeal Carcinoma.- Burkitt’s Lymphoma.- Inherited Immune Deficiency and Lymphoproliferative Malignancies.- Hematopathology of X-Linked Lymphoproliferative Syndrome.- Responses to Epstein-Barr Virus in Immune Deficient Patients.- Immunodeficiency to Epstein-Barr Virus in Chediak-Higashi Syndrome.- Model Systems for Epstein-Barr Virus-Target Cell Interaction.- Expression of Virus-Associated Functions in Cells Transformed In Vitro by Epstein-Barr Virus: Epstein-Barr Virus Cell Surface Antigen and Virus-Release From Transformed Cells.- In Vitro Modulation of Epstein-Barr Virus-Carrying Lymphoblastoid Cell Lines.- Epstein-Barr Virus in New Host Cells.- Biology of Epstein-Barr Virus.- Herpesvirus-Induced Lymphoproliferative Diseases in Non-Human Primates.- Relationship of Immune Deficiency and Oncogenic Viruses to Malignant B Cell Lymphomas: Mouse and Man.- Acquired Immune Deficiency and Lymphoproliferative Disorders.- Allograft Transplant Cancer Registry.- Lymphoma in Cardiac Transplant Recipients Associated with Cyclosporin A, Prednisone, and Anti-Thymocyte Globulin (ATG).- Lymphoproliferative Diseases in Renal Allograft Recipients.- Chronic Mononucleosis.- The Syndrome of Acquired Immunodeficiency Among a Subset of Homosexual Men.- Lymphoproliferative Diseases and Kaposi’s Sarcoma in Homosexual Males.- Genetic Factors in Lymphomagenesis.- Mendelian Predisposition to Lymphomagenesis.- Chromosomal Defects and Their Role in Lymphomagenesis.- Prevention of Epstein-Barr Induced Diseases in Immunodeficient Individuals.- Interferon Therapy in Herpes Virus Infections.- Epstein-Barr Virus and Marrow Transplantation Recipients.- Immunoreconstitution by Bone Marrow Transplantation Decreases Lymphoproliferative Malignancies in Wiskott-Aldrich and Severe Combined Immune Deficiency Syndromes.- Contributors.