I Domain Integrins

ISBN-13: 9789402402902 / Angielski / Miękka / 2016 / 179 str.

Donald Gullberg

Opis

The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.

Spis treści

Preface

1 Evolution of integrin I domains
Mark S. Johnson, and Bhanupratap Singh Chouhan

2 Integrin a1b1
Humphrey Gardner

3 Integrin a2b1
Asakiran Madamanchi, Samuel A. Santoro, and Mary M. Zutter

4 Integrin a10b1- a collagen receptor critical in skeletal development
Evy Lundgren-Åkerlund and Attila Aszodi

5 Integrin a11b1 – a major collagen receptor on fibroblastic cells
Cédric Zeltz, Ning Lu, and Donald Gullberg

6 Regulation of integrin activity by phosphorylation
Carl G. Gahmberg, Mikaela Grönholm, and Liisa M. Uotila

7 Integrin aEb7:molecular features and functional significance in the immune system
Gregg A. Hadley and Jonathan M.G. Higgins

8 Structural aspects of integrins
Robert C. Liddington

9 Integrin recognition motifs in the human collagens
Samir Hamaia and Richard Farndale

10 Cellular signalling by collagen-binding integrins
Jyrki Heino

11 The therapeutic potential of I-domain integrins
Marian Breenan and Dermot Cox

Index.