Hypoxia: From Genes to the Bedside

ISBN-13: 9780306466960 / Angielski / Twarda / 2002 / 445 str.

Robert C. Roach; Peter D. Wagner; Peter H. Hackett

Opis

Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

Spis treści

Tribute to John T. Reeves.- 1. John T. Reeves, MD.- From Genes to the Bedside.- 2. Genetic lessons from high altitude.- 3. Genes, environment, and exercise.- 4. Skeletal muscle angiogenesis.- 5. Leukocyte-endothelial interactions in environmental hypoxia.- Training at Altitude for Sea Level Performance.- 6. Hypoxia training for sea-level performance.- 7. The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise.- High Altitude Pulmonary Edema.- 8. Update: High altitude pulmonary edema.- Comparative Biology.- 9. Phylogenetic comparison and artificial selection.- 10. Genetic and environmental adaptation in high altitude natives.- 11. Common themes of adaptation to hypoxia.- Erythropoietin.- 12. Biology of erythropoietin.- 13. Lessons to better understanding of hypoxia sensing.- 14. Erythropoietin use and abuse.- Mountain Medicine.- 15. Mountaineering in thin air.- 16. Weight loss at high altitude.- Stress Proteins and Hypoxia.- 17. The heme oxygenase system and cellular defense mechanisms.- 18. Hypoxia-inducible factor in brain.- Transepithelial Sodium Transport.- 19. Proton-gated cation channels — neuronal acid sensors in the central and peripheral nervous system.- 20. Structure function relationships of ENaC and its role in sodium handling.- 21. Transepithelial sodium and water transport in the lung.- Advances in Cardiorespiratory Control in Hypoxia.- 22. Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?.- 23. Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia.- 24. The pVHL-HIF-1 system.- Frontiers in Hypoxia Research.- 25. Interval hypoxic training.- 26. Gene transfer and metabolic modulators as new therapies for pulmonary hypertension.- 27. Chronic mountain sickness.- 28. International Working Group for Chronic Mountain Sickness.- 29. Late and Amended Abstracts.