Hypertension and the Heart

ISBN-13: 9781461374589 / Angielski / Miękka / 2012 / 288 str.

Alberto Zanchetti; Richard B. Devereux; Lennart Hansson

Opis

Left ventricular hypertrophy represents one of the most common complications of the hypertensive state. Indeed, since the Framigham Heart Study, several epidemiological studies have provided clearcut evidence that cardiac hypertrophy represents an important and independent risk factor for the hypertensive patient. Since the introduction of quantitative ultrasound techniques to evaluate cardiac function and state, the research in the field of left ventricular hypertrophy has been par- ticularly active and fruitful, allowing us to gain new information on the pathophysiology of this condition and on its diagnostic and therapeutic approach. The international symposium "Hypertension and the Heart," one of the most impor- tant meetings held on this issue in recent years, promoted by Fondazione Internazionale Menarini, dealt with cardiac hypertrophy in its structural, molecular, pathophysiological, and clinical aspects, and with related complications, such as myocardial ischemia, arrhyth- mias, and congestive heart failure. Prof. A. Zanchetti v CONTENTS Session I: Left Ventricular Hypertrophy: Structural Aspects and Mechanisms 1. Relations of Left Ventricular Geometry and Function to Prognosis in Hypertension .............................................. . Richard B. Devereux, Giovanni de Simone, and Mary J. Roman 2. Left Ventricular Hypertrophy, Arterial Compliance, and Aging .............. 13 Mary 1. Roman, Antonello Ganau, Pier Sergio Saba, and Richard B. Devereux 3. Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension . . . . . . . . . . . . . . . . . . . . . . 23 . . . . . . .

Spis treści

Session I: Left Ventricular Hypertrophy: Structural Aspects and Mechanisms.- 1. Relations of Left Ventricular Geometry and Function to Prognosis in Hypertension.- 2. Left Ventricular Hypertrophy, Arterial Compliance, and Aging.- 3. Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension.- 4. Regulation and Role of Myocardial Collagen Matrix Remodeling in Hypertensive Heart Disease.- 5. Ultrasonic Reflectivity of the Heart: A Measure of Fibrosis?.- 6. Local Angiotensin II and Myocardial Fibrosis.- 7. Left Ventricular Anatomy and Function in Primary Aldosteronism and Renovascular Hypertension.- Session II: Pathophysiological and Molecular Aspects.- 8. Hypertension Differentially Affects the Expression of the Gap Junction Protein Connexin43 in Cardiac Myocytes and Aortic Smooth Muscle Cells.- 9. Modulation of Cardiac Hypertrophy by Estrogens.- 10. Salt Sensitivity and Left Ventricular Hypertrophy.- 11. Volume Overload, Atrial Natriuretic Peptide, and Left Ventricular Hypertrophy.- 12. The Renin-Angiotensin System Gene Polymorphism and Left Ventricular Hypertrophy.- 13. Renin-Angiotensin System Gene Polymorphisms and Left Ventricular Hypertrophy: The Case against an Association.- Session III: Pathophysiological and Therapeutic Aspects.- 14. Left Ventricular Hypertrophy and Arterial Hypertrophy.- 15. Relationship between Cardiac Hypertrophy and Microalbuminuria.- 16. Physiological versus Pathological Hypertrophy: The Athlete and the Hypertensive.- 17. Bradykinin and Cardiac Protection.- 18. Left Ventricular Hypertrophy and Sympathetic Activity.- 19. Hypertension, Left Ventricular Hypertrophy, and Heart Rate Variability.- 20. Comparison of Meta-Analyses of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 21. Comparison of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 22. Prognostic Significance of Left Ventricular Hypertrophy Regression.- Session IV: Myocardial Ischemia.- 23. Hypertension and Coronary Microvascular Disease.- 24. Myocardial Perfusion in Hypertensive Patients with Normal Coronary Arteries.- 25. Endothelial Dysfunction in Hypertension.- 26. Endothelial Dysfunction in Hypertensives: An Uncertain Association.- 27. Hypertension, Left Ventricular Hypertrophy, and Coronary Flow Reserve.- 28. Hypertensive Heart Disease, Ventricular Dysrhythmias, and Sudden Death.- 29. Hypertension and Heart Failure.- Speakers.