Human Placental Trophoblasts: Impact of Maternal Nutrition

ISBN-13: 9781482254280 / Angielski / Twarda / 2015 / 426 str.

Asim K. Duttaroy; Sanjay Basak

Opis

Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critical role of nutrients on human placental development and its' in utero programming effects on the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and obesity in later life. The book begins with discussions of the central process of placentation and its regulation on size and growth of the fetus. It also covers the effects of key macronutrients on placental growth, metabolism, transport, and secretory function. The text details important vitamins and few micronutrients and their roles in the feto-placental growth and development. It includes information on the influence of maternal lifestyle and environmental factors on regulation of the growth, metabolism and gene expression in the feto-placental unit. A review of the genes linked to the process of placentation rounds out the coverage. An examination of a broad range of evidence in the areas of placental growth, function, and its impact on feto-placental outcome, the book presents new knowledge on nutrition and its relevance with early human development. This includes not only the effects of maternal nutrients on possible neonatal growth and development but also their regulation by maternal lifestyle associated factors. A fine blending of epidemiology, clinical nutrition, perinatal and neonatal medicine, and biochemistry and molecular biology areas of research activities, the book helps you to understand the impact of maternal nutrition on placentation and its relevance with pregnancy outcome and fetal programming of adult health and disease.

Spis treści

Preface. Overview of the Book. Organization of Human Placenta and Structure and Function of Trophoblast. Introduction to the Key Nutrients and Their Implication on Placentation. Amino Acid Transport and Metabolism of the Trophoblast Cells. Transport and Metabolism of Lipids in Trophoblast Cells. Maternal Lipid and Their Impact on Angiogenesis and Invasion of Trophoblast. Folic Acid, Vitamin B12, Vitamin D on Cellular Growth, Angiogenesis and Invasion of Trophoblast. Nuclear Transcription Factors and Their Effect on Trophoblast Metabolism. Effect of Adipokines on Angiogenesis and Invasion of the Trophoblast Cells. Hyperglycemia and Hypoxia on Angiogenesis and Invasion of the Trophoblast Cells. Regulation of Gene Expression During Angiogenesis and Invasion of the Trophoblast. Index.