1. Introduction 2. Human-Organ-on-Chip 3. Technology for Organ-on-Chip Applications 4. Microfluidics Theory in Organ-on-Chip 5. Fundamentals 6. Measurement and Analytical Techniques 7. Major on-chip applications 8. Multi-organ-on-Chip 9. Organ-on-chip-based Disease Models 10. Commercial Achievements thanks to Multi-Organ-on-Chip Applications 11. Further Perspectives - New Drugs, New Tissues, New Organs 12. Conclusions