Human Cytogenetic Cancer Markers

ISBN-13: 9780896033573 / Angielski / Twarda / 1997 / 485 str.

Sandra R. Wolman; Stewart Sell

Opis

Seventeen cutting- edge chapters review both basic research and clinical role in

Recenzje

". . .well written and well illustrated. . .contains a wealth of information. . .recommend[ed] to all pathologists who have an interest in the genetic mechanisms involved in cancer and to all pathologists who direct a cytogenetics or molecular genetics laboratory."-American Journal of Clinical Pathology

Spis treści

Part I. Perspectives: Relation of Other Genetic Measures to Cytogenetics. An Introduction to Cancer Markers and Cytogenetics, Sandra R. Wolman, Stewart Sell, and Eric Wolman. Assessment of Genetic Changes in Human Cancers Using Flow and Image Cytometry, T. Vincent Shankey and Cees J. Cornelisse. In Situ Hybridization and Comparative Genomic Hybridization, Anton H. N. Hopman, Christina E. M. Voorter, Ernst J. M. Speel, and Frans C. S. Ramaekers. Nucleic Acid Amplification Methods for Identifying Cytogenetic Abnormalities, Timothy J. O'Leary. Part II. Organ and Site-Specific Tumors. Direct Demonstration of Lineage Specificity in Hematologic Neoplasms, Sakari Knuutila. Breast Tumor Cytogenetic Markers, Marilyn L. Slovak. Karyotypic Characteristics of Colorectal Cancer, Georgia Bardi, Nikos Pandis, Felix Mitelman, and Sverre Heim. Renal and Bladder Cancers, Jonathan A. Fletcher. Cytogenetic Markers in Selected Gynecological Malignancies, Urvashi Surti and Lori Hoffner. Prostate Cancer, Arthur R. Brothman and Briana J. Williams. Chromosomes in Lung Cancer, Daphne W. Bell and Joseph R. Testa. Cytogenetic Biomarkers in Skin Cancer, Maria J. Worsham, S. David Nathanson, Min Lee, and Sandra R. Wolman. Brain Tumors, Joan Rankin Shapiro and Adrienne C. Scheck. Cytogenetic Abnormalities Associated with Endocrine Neoplasia, Stefan K. G. Grebe, Norman L. Eberhardt, and Robert B. Jenkins. Pancreatic Exocrine Tumors, Constance A. Griffin. Soft Tissue Sarcomas, Julia A. Bridge. Special Techniques in Cytogenetics, Linda A. Cannizzaro. Index.

Blurb

Human Cytogenetic Cancer Markers provides state-of-the-art reviews of both basic research and clinical applications of the chromosomal markers of cancer. These new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The contributors-all leading researchers and practitioners in the field-insightfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated.

Human Cytogenetic Cancer Markers describes the emerging utility of molecular markers in the precise and specific definition of tumors and their behavior, thus establishing these genetic markers as the most accurate means to diagnose cancer and predict its course. Wolman and Sell have produced a seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.