Human Blood Groups: Chemical and Biochemical Basis of Antigen Specificity

ISBN-13: 9783211834718 / Angielski / Twarda / 2000 / 640 str.

Helmut Schenkel-Brunner; H. Schenkel-Brunner

Opis

As President and organiser of the 26th Congress of the International Society pf Blood Transfusion 'ISBT 2000', I am pleased to introduce this work on the biochemistry of human blood groups, which will serve as a valuable complement to blood group serology work. For this new edition the author has singlehandedly covered virtually all blood group research published before the current year. It is my firm belief that all participants in the ISBT conference will find this book a highly useful addition to their scientific libraries. Vienna, April 2000 W.R. Mayr Congress President Preface This revised and updated edition of the monograph on the chemistry and biochemistry of human blood groups is being published to honour the 1 Oath anniversary of Dr. Karl Landsteiner's discovery of human blood groups here in Vienna. Five years have passed since publication of the first edition, and in this time research on the biochemistry of human blood groups has reached staggering proportions. Thanks to extensive molecular biological applications, research groups have identified the bearer molecules of even more blood groups, and are now able to clarify the molecular basis of a vast number of blood group specificities. Human blood group research has become one of the most fruitful of all biochemical research fields. While this development is immensely gratifying to a researcher like myself, who has worked in human blood groups for the past 34 years, coping with the close to overwhelming number of publications has proved a highly challenging task.

Recenzje

"... This book is well organized, accurate ... Helmut Schenkel-Brunner is to be congratulated on compiling and presenting the information in a clear and consice manner ... "Human blood groups: chemical and biochemical basis of antigen specificity” is a useful reference book for the shelf of those interested in understanding the biochemical and genetical aspects of blood group antigens.” Human Genetics 2001

Spis treści

INHALT LANG: Introduction Glycoconjugates Glycolipids; Glycoproteins Biosynthesis of Glycoconjugates Biosynthesis of Glycoproteins; Biosynthesis of Glycosphingoliopids; Regulation of Chain Structure Erythrocyte Membrane Constituents of the Erythrocyte Membrane; Molecular Architecture of the Erythrocyte Membrane; Architecture of the Membranes of Nucleated Cells ABO(H) System Genetics; Antisera and Lectins; Blood Group ABH Substances; Biosynthesis of ABH Antigens and its Genetic Regulation; ABH Subgroups and Variants Lewis System and the Antigens Lex and Ley Genetics; Antisera and Lectins; Blood Group Lewis Substances; Biosynthesis of Blood Group Lewis Determinants; Antigens Lex and Ley Antigens I and i Antisera; Blood Group I and i Determinants; Blood Group I and i Substances; Expression of I and i Activity During Embryonic Development and under Various Pathological Conditions; Biosynthesis of I and i Determinant Structures P System Antisera and Lectins; Blood Group P Substances; Biosynthesis of the Blood Group P Antigens MNS System Genetics; Antisera and Lectins; Blood Group MNS Substances; Structure and Organisation of the MNS Gene Complex; Chemical Structures of the Main Determinants of the MNS System; Rare Variants of the MNS Antigens; MNS-Deficient Phenotypes, and Antigens Associated with MNS System Polyagglutination Antisera and Lectins; T Antigen; Tk Antigen; Th Antigen; Tx Antigen; Tn Antigen; VA and NOR Sid and Cad Antisera and Lectins; Sda Active Substances; Cad Active Substances; Investigations on the Biosynthesis of Sda and Cad Determinants Slalic Acid-Containing Receptors for Cold Agglutinins Antisera; Structures of Antigenic Determinants; Occurrence of Pr, Gd, and Sa Antigens on Other Cell Types; Other Receptors for Cold Agglutinins Rh System Genetics; Rh Antisera, Chemical Properties of Rh Antigens; Number of Rh Proteins; Molecular Biological Investigations; Rh Antigens and Phenotypes Landsteiner-Wiener System Chido / Rodgers System Duffy System Kell System Antibodies; Kell-Deficient Phenotypes; Kell Glycoprotein; Kell Alleles; Kx Antigen Gerbich System Glycophorin C and Glycophorin D; The Antigen Characters Ge1, Ge2, Ge3, and Ge4, and the Lsa Determinant; Wb (Webb); Dha (Duch); Ana (Ahonen) Lutheran System Diego System Antibodies; The Antigens of the Diego System Cromer System Dombrock System Yt System Indian System Knops System Kidd System Xg System Colton System OK System JMH Antigen Antigens of the Major Histocompatibilitiy Complex (HLA Antigens) Genetics; HLA Antisera; HLA Gene Products HEMPAS Carcinoembryonic Antigen (CEA) Family