Hot Topics in Neural Membrane Lipidology

ISBN-13: 9781441918826 / Angielski / Miękka / 2010 / 408 str.

Akhlaq A. Farooqui

Opis

Glycerophospholipid and sphingolipid-derived lipid mediators facilitate the transfer of messages not only from one cell to another but also from one subcellular organelle to another. These molecules are not only components of neural membranes but also storage depots for lipid mediators. Information on the generation and involvement of lipid mediators in neurological disorders is scattered throughout the literature in the form of original papers and reviews. This book will provide readers with a comprehensive description of glycerophospholipid, sphingolipid and cholesterol-derived lipid mediators and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge and comprehensive information on lipid mediators in a manner that is useful not only to students and teachers but also to researchers and physicians. This monograph has 11 chapters. Chapters 1 and 2 describe the generation of various lipid mediators from neural membrane glycerophospholipids, sphingolipids, and cholesterol, and their involvement and roles in signal transduction processes. Chapters 3 and 4 describe cutting edge information on roles of various isoforms and paralogs of phospholipases A₂ in the generation of glycerophospholipid-derived lipid mediators and interactions among phospholipases A₂, C, and D in the nucleus. Chapter 5 describes metabolism and roles of bioactive ether lipids in brain. Chapters 6 and 7 are devoted to excitotoxicity-mediated modulation of lipid mediators in neurological disorders and recent developments in kainic acid-induced neurotoxicity. Chapters 8 and 9 describe the health benefits of n-3 fatty acids (docosahexaenoic and eicosapentaenoic acids) in diet, the mechanisms of their action in cardiovascular and cerebrovascular systems, and comparison of n-3 fatty acid s effect with cholesterol lowering drugs (statins). Chapter 10 describes the contribution of neural membrane lipids in apoptosis and necrosis. Finally, Chapter 11 provides readers and researchers with a perspective that will be important for future research work on bioactive lipid mediators. This book will be particularly accessible to neuroscience graduate students and teachers, as well as researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in neurodegeneration in acute neural trauma (stroke, spinal cord trauma and head injury) and neurodegenerative diseases (Alzheimer disease, Parkinson disease, and Huntington disease). This monograph will be the first to provide a comprehensive description of glycerophospholipid, sphingolipid, and cholesterol-derived mediators, their interactions with each other in normal brain and in brain tissue from neurological disorders. "

Spis treści

Neural Membranes: A Pandora’s Box of Lipid Mediators.- Interplay Among Glycerophospholipid, Sphingolipid, and Cholesterol-Derived Lipid Mediators in Brain: A Matter of Life and Death.- Janus Face of Phospholipase A2: Role of Phospholipase A2 in Neural Cell Survival and Death.- Glycerophospholipid Metabolism in the Nucleus: Cross Talk Among Phospholipase A2, Phospholipase C and Phospholipase D.- Ether Glycerophospholipids: The Workhorse Lipids of Neural Membranes.- Excitotoxicity-Mediated Neurochemical Changes in Neurological Disorders.- Recent Developments on Kainate-Mediated Neurotoxicity and Their Association with Generation of Lipid Mediators.- Beneficial Effects of Docosahexaenoic Acid on Health of the Human Brain.- Effects of Statins and n–3 Fatty Acids on Heart and Brain Tissues: The Clash of the Titans.- Apoptosis and Necrosis in Brain: Contribution of Glycerophospholipid, Sphingolipid, and Cholesterol-Derived Lipid Mediators.- Perspective and Directions for Future Developments on Glycerophospholipid-, Sphingolipid-, and Cholesterol-Derived Lipid Mediators.

O autorze

About the Author:

Akhlaq A. Farooqui is a leader in the field of brain phospholipases A₂, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A₂ activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. He has authored three monographs: Glycerophospholipids in Brain: Phospholipase A₂ in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.

Blurb

Not only do glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators facilitate the transfer of messages from one cell to another, they also facilitate communication among subcellular organelles. Hot Topics in Neural Membrane Lipidology provides readers with a cutting-edge, comprehensive review of these lipid mediators, their roles and association with neurological disorders, and the future direction of research on the topic. 

This monograph provides readers with critical data and is particularly accessible to neuroscience graduate students, teachers, and researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in acute neural trauma like stroke, spinal cord trauma, head injury, and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease.

About the Author:

Akhlaq A. Farooqui is a leader in the field of brain phospholipases A₂, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A₂ activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. Dr. Farooqui has authored three monographs: Glycerophospholipids in Brain: Phospholipase A₂ in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.