Hormones and the Endocrine System: Textbook of Endocrinology

ISBN-13: 9783319792125 / Angielski / Miękka / 2019 / 437 str.

Bernhard Kleine; Winfried G. Rossmanith

Spis treści

Introduction.-History of Hormones and Endocrinology.- I. Hormone biochemistry.-Hormones: Definitions.-Vertebrate Protein and Peptide Hormones.-Invertebrate protein and peptide hormones.-Hormones from Mevalonate: JH and Steroids.-Hormones Derived by Amino Acid Conversion.-Receptors.-II. Endocrine physiology.-Synthesis, Release, and Action.-Endocrine active organs.-Regulatory Patterns.-Endocrine Rock 'n Roll: Rhythms and Secretion.- Evolution of the Endocrine System.-III. Hormones and medicine.-Diseases of the Endocrine System.-Boosting Performance-Legally or Not.-IV. Appendix.-A. Appendix.-B. References.-C. Index

O autorze

Bernhard Kleine studied Chemistry but later on turned to endocrinology and worked as scientist in Winfried Rossmanith´s laboratories at the universities of Ulm and Karlsruhe. He then went into Clinical Research and gained expertise in Drug Supply management, Contract management, SOP training and Clinical database design. Currently he is programming the simulation of clinical study supply to determine feasibility and costs of almost any study.

Winfried Rossmanith is physician and head of the department of the gynecological hospital of the Klinikum Mittelbaden Baden-Baden Balg. He was laboratory leader at the university of Ulm.

Blurb

This book focuses on hormones, and on how they are produced in very diverse regions of the body in humans and animals. Hormones exhibiting the same synthesis pathways are not only found in vertebrates, but also in insects, shellfish, spiders, mollusks, and they were present evenat the time of metazoan diversification. The book discusses the different classes of hormones: protein/peptides hormones, steroids and juvenile hormones and hormones like catecholamines, thyroid hormones and melatonin. It also discusses the different types of hormone receptors, the majority of which are heptahelical G-protein coupled receptors or nuclear receptors. Particular attention is paid to the organs where hormones are synthesized, with specifics on production and release, while a dedicated chapter details hormonal regulation in systems ranging from the very simple to the highly complex. The remarkable kinetics of hormone production is also shown, and the book is rounded out by chapters on the evolution of the endocrine system, the genetics of endocrine diseases and doping.