Homocysteine Metabolism in Health and Disease

ISBN-13: 9789811668661 / Angielski / Twarda / 2022

Opis

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Spis treści

Chapter 1_Overview of homocysteine. –Chapter 2_Homocysteine and Folic acid metabolism. –Chapter 3_ Hyper-homocysteinemia and nutrition. –Chapter 4_ Metabolic disorders and Homocysteine. –Chapter 5_Bone Health and homocysteine. –Chapter 6_Biofortification, homocysteine and nutrition. –Chapter 7_ Homocysteinemia and autoimmune diseases. –Chapter 8_Homocysteine metabolism pathway genes in risk of type-2 diabetes mellitus. –Chapter 9_Role of homocysteine metabolism in cardiovascular diseases (CVD). –Chapter 10_ Homocysteine and thyroidism. –Chapter 11_Homocysteine metabolism and cancer. –Chapter 12_Stem cell and Homocysteine metabolism in treatment and management of diseases. –Chapter 13_Homocysteine in Nutritional Determinants; Genetic Susceptibility to Neural Tube Defect (NTD). –Chapter 14_Homocysteine metabolism dependent computational drug development: current status and future perspectives. –Chapter 15_Hyper-homocysteinemia mediated neuro-inflammation and neurodegenerative disorders. –Chapter 16_Homocysteinemia and viral infection (Covid-19).

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O autorze

Prof. Govind Prasad Dubey is designated as a Lifelong Distinguished Professor at Department of Kriya Sharira; and has profound expertise in scientific validation of Indigenous System of Medicine. He also bears the responsibility of Study Director and Coordinator, DST Tribal Medicine Project, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh. Prof. Dubey has more than 50 years of teaching, research and administrative experience and has been felicitated with various posts of International and National significance. He is distinguished member of several scientific committee including, Indian delegation led by Prime minister of India to USA. Prof. Dubey has received several International and Nation Funds/Grants including; Department of AYUSH, Department of Science and Technology (DST), Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR), New Delhi and other government body in collaboration with multinational companies including; Jinvator BioMed GmbH, Germany in different areas of Herbal/Ayurveda drug development. He has published more than 250 research articles, 05 books, and holds 24 patents of USA, European and Indian continent.

Prof (Mrs.) Krishna Misra is an Honorary Professor, Indian Institute of Information Technology, Prayagraj, U.P. She superannuated as a Professor of Chemistry at University of Allahabad, where she occupied the chair of head, Biochemistry department and was first coordinator of the Centre for Biotechnology. At present, she is fellow of The National Academy of Sciences, Allahabad and also worked as General Secretary. Besides, she is chief advisor, India Pesticides Ltd., Lucknow and had been member advisory board, Biotech Park, Lucknow. She was awarded NASI Platinum Jubilee senior scientist Fellowship. She is chairperson of STEM program of DST and Chemistry advisory board of UPCST. She had been expert in many selection committees including KGMU, SGPGIMS Lucknow and is also on editorial boards of many national and international journals. She published 250 papers, four books, and has Indian and US patents to her credit. Had been member task force of Department of Biotechnology, Govt of India, Fellow and founder member of BRSI (Biotechnology Research society of India). Member advisory board, Molecular Medicine, SGPGI, Lucknow. Written a dozen book chapters presented papers in about 100 national and international conferences, has Indian and US patents, visited Japan (UNESCO fellow), U. K. (Sponsor British Council), USA (Invited papers/talks/chair) number of times to deliver lectures and participate in scientific discussions. Prof. Misra have been awarded a large no. of research projects including three prestigious international projects from USA.

Dr. Rajesh Kumar Kesharwani is an Associate Professor, Department of Computer Application, Nehru Gram Bharati, Deemed University, Prayagraj, U.P., India. He has more than 12 years of research and 9 years of teaching experience in various institutes of India. He has received several awards, including The NASI-Swarna Jayanti Puruskar by The National Academy of Sciences, of India. He has authored over 55 peer reviewed articles, 25 book chapters and 13 edited Books with international publishers. He has been a member of many scientific communities as well as a reviewer for many international journals. His research fields of interest are Medical Informatics, Protein Structure and Function Prediction, Computer-Aided Drug Designing, Herbal Drug Development, Cancer Biology, Nano-Biotechnology, and Biomedical Sciences.

Dr. Rudra Prakash Ojha is designated as Director, Research Centre and Associate Professor in department of Zoology, Faculty of Science, Nehru Gram Bharati, Deemed University, Prayagraj, U.P. India. He has more than 16 years of teaching, research and administrative experience from various National and International reputed institutes including; Institute of Pathology, ICMR, AIIMS-New Delhi, NIMHANS, Bangalore, Banaras Hindu University, Varanasi and University of California, Davis, CA, USA. He has authored 36 research articles, 09 book chapters and 03 edited books of National and International repute. Dr. Ojha has been conferred with various prestigious International and National awards notably; Young Scientist Award from Dept. of Science & Technology (DST), New Delhi, Full Travel support grant from Dept. of AYUSH, New Delhi for overseas presentation at World Congress of Oxygen, Club of California, Santa Barbara, California, USA. Dr. Ojha is lifetime member of many national and international societies including Society for Neurosciences (SfN), USA, Society for Free Radical Research (SFRR), Europe and Indian Academy of Neurosciences (IAN), India. His field of research interest in Herbal Drug Development, Cancer biology, Neuroscience and Biomedical Sciences.