Homeostasis - Tumor - Metastasis

ISBN-13: 9789402402483 / Angielski / Miękka / 2016 / 279 str.

Gaspar Banfalvi

Opis

Homeostasis. The health of an organism is influenced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It will be answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer.
Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation.
Metastasis. Animal tumor models serve to understand the spread of the primary tumor cells to distant locations of the organism. Different types of tumors and metastases will be reviewed.​

Spis treści

Preface
1. Homeostasis
Chemical basis of biological regulation
Definition of homeostasis, allostasis
Aqueous internal environment
Optimal systems
Basic properties of living systems
Metabolism and energy production of living systems
Contribution of biological membranes to homeostasis
Function of the inner environment and its regulated parameters
Cellular, tissue and organ homeostasis
Dimensions of health
Control of processes
Levels of bioregulation
Regulation of multicellular organisms
Major regulatory systems of organisms
Regulatory mechanisms: receptors, reflexes
Maintaining human homeostasis
Evolutionary aspects and types of regeneration
Panic syndromes
References
2. Cell cultures
Cell cultivation
Cell cultures
Establishment of cell cultures
Development of primary tumors
Growth of cell lines
Technical aspects of cell cultivation
Sterile work under the laminar flow hood
Deep freezing, storage of cells
Cell cycle synchronization and its flow cytometric validation
Stem cells
References
3. Loss of homeostasis
Loss of biological balance
Tissue adaptation
Pathological hypertrophies
Heloma
Callus formation
Liver regeneration
References
4. Tumor development
Characterization of benign and malignant tumors
Primary tumor models
Classification of tumors
Tumor tests
Carcinogens
Techniques of tumor screening
Antitumor agents
Benign tumor formation in different tissues and their treatment
General steps in tumor formation
Benign tumors of major organs
References
5. Metastasis
Historical view of metastasis
Spread of tumor cells from local tissue to distant organs
Animal cancer models
Role of parathymic lymph nodes in metastasis
Importance of size distribution of tumor cells in metastasis
Metastasis in different organs
References
Abbreviations

 

 

Blurb

Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.