Holland-Frei Cancer Medicine

ISBN-13: 9781119750680 / Angielski / Twarda / 2023 / 2176 str.

Robert C. Bast; Carlo M. Croce; William N. Hait

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List of contributors xiPreface xxviiAcknowledgments xxixPart 1: INTRODUCTION1 Cardinal manifestations of cancer 3James F. Holland, Robert C. Bast, Jr., John C. Byrd,Carlo M. Croce, Ernest Hawk, Fadlo R. Khuri, RaphaelE. Pollock, Apostolia M. Tsimberadou, Christopher G.Willett, and Cheryl L.Willman2 Biological hallmarks of cancer 7Douglas Hanahan and Robert A.WeinbergPart 2: TUMOR BIOLOGY3 Molecular biology, genetics, and translationalmodels of human cancer 19Benno Traub, Florian Scheufele, Srinivas R.Viswanathan, Matthew Meyerson, and David A. Tuveson4 Oncogenes 49Marco A. Pierotti, Milo Frattini, Samantha Epistolio,Gabriella Sozzi, and Carlo M. Croce5 Tumor suppressor genes 73Fred Bunz and Bert Vogelstein6 Epigenetic contributions to human cancer 89Stephen B. Baylin7 Cancer genomics and evolution 101William P. D. Hendricks, Aleksandar Sekulic, Alan H.Bryce, Muhammed Murtaza, Pilar Ramos, Jessica D.Lang, Timothy G. Whitsett, Timothy K. McDaniel,Russell C. Rockne, Nicholas Banovich, and Jeffrey M. Trent8 Chromosomal aberrations in cancer 125Megan E. McNerney, Ari J. Rosenberg, and Michelle M.Le Beau9 MicroRNA expression in cancer 143Serge P. Nana-Sinkam, Mario Acunzo, and Carlo M. Croce10 Aberrant signaling pathways in cancer 151Luca Grumolato and Stuart A. Aaronson11 Differentiation therapy 161Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, andZhu Chen12 Cancer stem cells 177Grace G. Bushnell,Michael D. Brooks, andMax S.Wicha13 Cancer and cell death 187John C. Reed14 Cancer cell immortality: targeting telomerase andtelomeres 201Ilgen Mender, Zeliha G. Dikmen, and JerryW. Shay15 Cancer metabolism 211Natalya N. Pavlova, Aparna D. Rao, Ralph J.DeBerardinis, and Craig B.Thompson16 Tumor angiogenesis 223John V. Heymach, Amado Zurita-Saavedra, ScottKopetz, Tina Cascone, MoniqueNilsson, and IreneGuijarroPart 3: QUANTITATIVE ONCOLOGY17 Cancer bioinformatics 247John N.Weinstein18 Systems biology and genomics 261Saima Hassan, Joe W. Gray, and LauraM.Heiser19 Statistical innovations in cancer research 269J. Jack Lee and Donald A. Berry20 Biomarker based clinical trial design in the era ofgenomic medicine 285R.Donald Harvey, Yuan Liu, Taofeek K.Owonikoko,and Suresh S. Ramalingam21 Clinical and research informatics data strategy forprecision oncology 293Douglas Hartman, Uma Chandran, Michael Davis,Rajiv Dhir,William E. Shirey, Jonathan C. Silverstein,and Michael J. BecichPart 4: CARCINOGENESIS22 Chemical carcinogenesis 305Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris23 Ionizing radiation 325David J. Grdina24 Ultraviolet radiation carcinogenesis 333James E. Cleaver, Susana Ortiz-Urda, and Sarah Arron25 Inflammation and cancer 339Jelena Todoric, Atsushi Umemura, Koji Taniguchi, andMichael Karin26 RNA tumor viruses 347Robert C. Gallo and Marvin S. Reitz27 Herpesviruses 359Jeffrey I. Cohen28 Papillomaviruses and cervical neoplasia 367Michael F. Herfs, Christopher P. Crum, and KarlMunger29 Hepatitis viruses and hepatoma 373HongyangWang30 Parasites 379Mervat El Azzouni, Charbel F. Matar, Radwa Galal,Elio Jabra, and Ali ShamseddinePart 5: EPIDEMIOLOGY, PREVENTION, ANDDETECTION31 Cancer epidemiology 391Veronika Fedirko, Kevin T. Nead, Carrie Daniel, andPaul Scheet32 Hereditary cancer syndromes: risk assessment andgenetic counseling 403Rachel Bluebond, Sarah A. Bannon, Samuel M. Hyde,Ashley H.Woodson, Nancy Y.-Q. You, Karen H. Lu, andBanu Arun33 Behavioral approaches to cancer prevention 425Roberto Gonzalez and Maher Karam-Hage34 Diet and nutrition in the etiology and preventionof cancer 433Steven K. Clinton, Edward L. Giovannucci, Fred K.Tabung, and Elizabeth M. Grainger35 Chemoprevention of cancer 453Ernest Hawk, Karen C. Maresso, Powel Brown, MichelleI. Savage, and Scott M. Lippman36 Cancer screening and early detection 473OtisW. BrawleyPart 6: CLINICAL DISCIPLINES37 Clinical cancer genomic diagnostics and moderndiagnostic pathology 493Katherine Roth, Stephen B. Gruber, and Kevin McDonnell38 Molecular diagnostics in cancer 505Zachary L. Coyne, Roshni D. Kalachand, Robert C. BastJr., Gordon B. Mills, and Bryan T. Hennessy39 Principles of imaging 519Lawrence H. Schwartz40 Interventional radiology for the cancer patient 521Zeyad A. Metwalli, Judy U. Ahrar, andMichael J. Wallace41 Principles of surgical oncology 531ToddW. Bauer, Kenneth K. Tanabe, and Raphael E. Pollock42 Principles of radiation oncology 543Scott R. Floyd, Justus Adamson, Philip P. Connell, RalphR.Weichselbaum, and Christopher G.Willett43 Principles of medical oncology 553Apostolia M. Tsimberidou, Robert C. Bast, Jr., Fadlo R.Khuri, and John C. Byrd44 Pain and palliative care 567Laura Van Metre Baum and Cardinale B. Smith45 Psycho-oncology 577Diya Banerjee and Andrew J. Roth46 Principles of cancer rehabilitation medicine 585Michael D. Stubblefield, Miguel Escalon, Sofia A.Barchuk, Krina Vyas, and David C.Thomas47 Integrative oncology in cancer care 593Gabriel Lopez,Wenli Liu, Santhosshi Narayanan, andLorenzo Cohen48 Health services research 599Michaela A. Dinan and Devon K. CheckPart 7: INDIVIDUALIZED TREATMENT49 Precision medicine in oncology drug development 613Apostolia M. Tsimberidou, Elena Fountzilas, andRazelle KurzrockPart 8: CHEMOTHERAPY50 Drug development of small molecule cancertherapeutics in an Academic Cancer Center 631Christopher C. Coss, Jeffrey T. Patrick, Damien Gerald,Gerard Hilinski, Reena Shakya, and John C. Byrd51 Principles of dose, schedule, and combinationtherapy 641Joseph P. Eder and Navid Hafez52 Pharmacology of small-molecule anticancer agents 655Zahra Talebi, Sharyn D. Baker, and Alex Sparreboom53 Folate antagonists 667Lisa Gennarini, Peter D. Cole, and Joseph R. Bertino54 Pyrimidine and purine antimetabolites 679Robert B. Diasio and StevenM. Offer55 Alkylating agents and platinum antitumorcompounds 693Zahid H. Siddik56 DNA topoisomerase targeting drugs 701AnishThomas, Susan Bates,William D. Figg, Sr., andYves Pommier57 Microtubule inhibitors 717Giuseppe Galletti and Paraskevi Giannakakou58 Drug resistance and its clinical circumvention 731Jeffrey A. Moscow, Shannon K. Hughes, Kenneth H.Cowan, and Branimir I. SikicPart 9: BIOLOGICAL AND GENE THERAPY59 Cytokines, interferons, and hematopoietic growthfactors 739Narendranath Epperla,Walter Hanel, and Moshe Talpaz60 Monoclonal antibody and targeted toxin therapy 755Robert C. Bast, Jr. andMichael R. Zalutsky61 Vaccines and immunomodulators 781Jeffrey Schlom, Sofia R. Gameiro, Claudia Palena, andJames L. Gulley62 T cell immunotherapy of cancer 789M. Lia Palomba, Jae H. Park, and Renier Brentjens63 Cancer immunotherapy 799Padmanee Sharma, Swetha Anandhan, Bilal A.Siddiqui, Sangeeta Goswami, Sumit K. Subudhi, JianjunGao, Karl Peggs, Sergio Quezada, and James P. Allison64 Cancer gene therapy 817Haruko Tashiro, Lauren Scherer, and Malcolm Brenner65 Cancer nanotechnology 825Xingya Jiang, Yanlan Liu, Danny Liu, Jinjun Shi, andRobert Langer66 Hematopoietic cell transplantation 833Qaiser Bashir, Elizabeth J. Shpall, and Richard E. ChamplinPart 10: SPECIAL POPULATIONS67 Principles of pediatric oncology 847Theodore P. Nicolaides, Elizabeth Raetz, andWilliam L.Carroll68 Cancer and pregnancy 867Jennifer K. Litton69 Cancer and aging 877Ashley E. Rosko, Carolyn J. Presley, Grant R.Williams,and Rebecca L. Olin70 Disparities in cancer care 885OtisW. Brawley71 Neoplasms in people living with humanimmunodeficiency virus 895Chia-Ching J.Wang and Elizabeth Y. Chiao72 Cancer survivorship 911Lewis FoxhallPart 11: DISEASE SITES73 Primary neoplasms of the brain in adults 921Matthew A. Smith-Cohn and Mark R. Gilbert74 Neoplasms of the eye and orbit 933Erica R. Alvarez, Claudia M. Prospero Ponce, PatriciaChevez-Barrios, and Dan S. Gombos75 Neoplasms of the endocrine glands and pituitaryneoplasms 943Rui Feng, Chirag D. Gandhi, Margaret Pain, andKalmon D. Post76 Neoplasms of the thyroid 949Matthew D. Ringel77 Malignant tumors of the adrenal gland 961Jeffrey E. Lee, Mouhammed A. Habra, andMatthew T.Campbell78 Tumors of the diffuse neuroendocrine andgastroenteropancreatic system 971Evan Vosburgh79 Neoplasms of the head and neck 981Robert L. Ferris, AdamS. Garden, andNabil F. Saba80 Cancer of the lung 1005Daniel Morgensztern, Daniel Boffa, Alexander Chen,Andrew Dhanasopon, Sarah B. Goldberg, Roy H.Decker, Siddhartha Devarakonda, Jane P. Ko, Luisa M.Solis Soto, Saiama N.Waqar, Ignacio I.Wistuba, andRoy S. Herbst81 Malignant pleural mesothelioma 1029Michele Carbone, Daniel R. Gomez, Anne S. Tsao,Haining Yang, and Harvey I. Pass82 Thymomas and thymic tumors 1043Mayur D. Mody,Gabriel L. Sica, Suresh S. Ramalingam,and Dong M. Shin83 Tumors of the heart and great vessels 1055Moritz C.Wyler von Ballmoos and Michael J. Reardon84 Primary germ cell tumors of the thorax 1061John D. Hainsworth and Frank A. Greco85 Neoplasms of the esophagus 1065MaxW. Sung and Virginia R. Litle86 Carcinoma of the stomach 1083Carl Schmidt, Nour Daboul, Carly Likar, and JoshuaWeir87 Primary neoplasms of the liver 1095Hop S. Tran Cao, Junichi Shindoh, and Jean-NicolasVauthey88 Gallbladder and bile duct cancer 1109Mariam F. Eskander, Christopher T. Aquina, andTimothy M. Pawlik89 Neoplasms of the exocrine pancreas 1123Robert A. Wolff, Donghui Li, AnirbanMaitra, SusanTsai, Eugene Koay, and Douglas B. Evans90 Neoplasms of the appendix and peritoneum 1139Annie Liu, Diana Cardona, and Dan Blazer91 Carcinoma of the colon and rectum 1147Yota Suzuki, Douglas S. Tyler, and Uma R. Phatak92 Neoplasms of the anus 1169Alexandre A. A. Jácome and Cathy Eng93 Renal cell carcinoma 1181Claude M. Grigg, Earle F. Burgess, Stephen B. Riggs,Jason Zhu, and Derek Raghavan94 Urothelial cancer 1191Derek Raghavan, Richard Cote, Earle F. Burgess, DerekMcHaffie, and Peter E. Clark95 Neoplasms of the prostate 1201Ana Aparicio, Patrick Pilie, Devaki S. Surasi, SeungtaekChoi, Brian F. Chapin, Christopher J. Logothetis, andPaul G. Corn96 Tumors of the penis and the urethra 1239Jad Chahoud, Andrea Necchi, and Philippe E. Spiess97 Testis cancer 1245Michael Hawking, Gladell Paner, Scott Eggener, andWalter M. Stadler98 Neoplasms of the vulva and vagina 1261Michael Frumovitz and Summer B. Dewdney99 Neoplasms of the cervix 1275Anuja Jhingran100 Endometrial cancer 1299Shannon N.Westin, Karen Lu, and Jamal Rahaman101 Epithelial ovarian, fallopian tube, and peritonealcancer 1311Jonathan S. Berek, Malte Renz, Michael L. Friedlander,and Robert C. Bast, Jr.102 Nonepithelial ovarian malignancies 1329Jonathan S. Berek, Malte Renz, Michael L. Friedlander,and Robert C. Bast, Jr.103 Molar pregnancy and gestational trophoblasticneoplasia 1343Neil S. Horowitz, Donald P. Goldstein, and Ross S. Berkowitz104 Gynecologic sarcomas 1351Jamal Rahaman and Carmel J. Cohen105 Neoplasms of the breast 1361Debu Tripathy, Sukh Makhnoon, Banu Arun, AysegulSahin, Nicole M. Kettner, Senthil Damodaran, KhandanKeyomarsi,Wei Yang, Kelly K. Hunt, Mark Clemens,Wendy A. Woodward, Melissa P.Mitchell, RachelLayman, Evthokia A. Hobbs, Bora Lim, MeganDupuis,Rashmi Murthy, Omar Alhalabi, Nuhad Ibrahim,Ishwaria M. Subbiah, and Carlos Barcenas106 Malignant melanoma 1413Michael J. Carr, JustinM. Ko, SusanM. Swetter, Scott E.Woodman, Vernon K. Sondak, Kim A. Margolin, andJonathan S. Zager107 Other skin cancers 1437Stacy L. McMurray,William G. Stebbins, Eric A.Millican, and Victor A. Neel108 Bone tumors 1451Timothy A. Damron109 Soft tissue sarcomas 1477Katherine A.Thornton, Elizabeth H. Baldini, Robert G.Maki, Brian O'Sullivan, Yan Leyfman, and Chandrajit P. Raut110 Myelodysplastic syndromes 1501Uma M. Borate111 Acute myeloid leukemia in adults: mast cellleukemia and other mast cell neoplasms 1517RichardM. Stone, Charles A. Schiffer, and Daniel J. DeAngelo112 Chronic myeloid leukemia 1537Jorge Cortes, Richard T. Silver, and Hagop Kantarjian113 Acute lymphoblastic leukemia 1547Elias Jabbour, Nitin Jain, Hagop Kantarjian, and SusanO'Brien114 Chronic lymphocytic leukemia 1559Jacqueline C. Barrientos, Kanti R. Rai, and Joanna M. Rhodes115 Hodgkin lymphoma 1569David J. Straus and Anita Kumar116 Clonal hematopoiesis in cancer 1579Philipp J. Rauch and David P. Steensma117 Non-Hodgkin's lymphoma 1587Arnold S. Freedman and Ann S. LaCasce118 Mycosis fungoides and Sézary syndrome 1603Walter Hanel, Catherine Chung, and John C. Reneau119 Plasma cell disorders 1611Andrew J. Yee, Teru Hideshima, Noopur Raje, andKenneth C. Anderson120 Myeloproliferative disorders 1633Jeanne Palmer and Ruben MesaPart 12: MANAGEMENT OF CANCERCOMPLICATIONS121 Neoplasms of unknown primary site 1647John D. Hainsworth and Frank A. Greco122 Cancer cachexia 1659Assaad A. Eid, Rachel Njeim, Fadlo R. Khuri, andDavid K.Thomas123 Antiemetic therapy 1673Michael J. Berger andDavid S. Ettinger124 Neurologic complications of cancer 1683Luis Nicolas Gonzalez Castro, Tracy T. Batchelor, andLisa M. DeAngelis125 Dermatologic complications of cancerchemotherapy 1701Anisha B. Patel, Padmavathi V. Karri, and Madeleine Duvic126 Skeletal complications 1715Michael A. Via, Ilya Iofin, Jerry Liu, and Jeffrey I. Mechanick127 Hematologic complications and blood banksupport 1729Roger Belizaire and Kenneth C. Anderson128 Coagulation complications of cancer patients 1739Tzu-FeiWang and Kristin Sanfilippo129 Urologic complications related to cancer and itstreatment 1747Omar Alhalabi, Ala Abudayyeh, and Nizar M. Tannir130 Cardiac complications 1757Michael S. Ewer, Steven M. Ewer, andThomas M. Suter131 Respiratory complications 1779Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez,Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura,Ajay Sheshadre, Scott E. Evans, Roberto Adachi,Michael Kroll, Saadia A. Faiz, DiwakarD. Balachandran, Selvaraj E. Pravinkumar,and Burton F. Dickey132 Gastrointestinal and hepatic complications incancer patients 1811Robert S. Bresalier, Emmanuel S. Coronel, and Hao Chi Zhang133 Oral complications of cancer and their treatment 1827Stephen T. Sonis, Anna Yuan, and Alessandro Villa134 Gonadal complications 1839RobertW. Lentz and Catherine E. Klein135 Sexual dysfunction 1849Leslie R. Schover136 Endocrine complications and paraneoplasticsyndromes 1855Sai-Ching J. Yeung and Robert F. Gagel137 Infections in patients with cancer 1869Harrys A. Torres, Dimitrios P. Kontoyiannis, andKenneth V.I. Rolston138 Oncologic emergencies 1883Sai-Ching J. Yeung and Carmen P. EscalantePart 13: THE FUTURE OF ONCOLOGY139 A vision for twenty-first century healthcare 1907Leroy Hood, Nathan D. Price, and James T. YurkovichIndex 1915

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Edited byRobert C. Bast Jr., MD, Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USAJohn C. Byrd, MD, The Gordon and Helen Hughes Taylor Professor and Chair, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USACarlo Croce, MD, Distinguished University Professor, The Ohio State University, The John W. Wolfe Chair in Human Cancer Genetics, Professor and Chair, Department of Cancer Biology and Genetics The Wexner Medical Center, The Ohio State University, Columbus, OH, USAErnest Hawk, MD, MPH, Vice President for Cancer Prevention & Head, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USAFadlo R. Khuri, MD, President and Professor of Internal Medicine, Hematology and Medical Oncology, The American University of Beirut, Beirut, LebanonRaphael Pollock, MD, PhD, FACS, Director, The Ohio State University Comprehensive Cancer Center, Kathleen Wellenreiter Klotz Chair in Cancer Research, The Ohio State University Wexner Medical Center, Columbus, OH, USAApostolia M. Tsimberidou, MD, PhD, Professor, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USAChristopher Willett, MD, Professor and Chair, Department of Radiation Oncology, Duke University School of Medicine, Boston, Massachusetts, USACheryl Willman, MD, Executive Director, Mayo Clinic Cancer Center Programs: Mayo Rochester/Midwest, Mayo Arizona, Mayo Florida, London, Abu Dhabi, Director, Mayo Clinic Comprehensive Cancer Center, Professor of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic Cancer Center, Rochester, NY, USA