Histocompatibility Testing 1984: Report on the Ninth International Histocompatibility Workshop and Conference Held in Munich, West Germany, May 6-11,

ISBN-13: 9783642697722 / Angielski / Miękka / 2011 / 764 str.

E. D. Albert; M. P. Baur; W. R. Mayr

Spis treści

Introductory Remarks.- Nomenclature for Factors of the HLA System 1984.- Joint Reports.- The HLA System, 1984.- HLA at the Gene Level.- Biochemistry of Class II Antigens: Workshop Report.- The Central Data Analysis of the Ninth Workshop.- Analysis of Multilocus Pedigree Data by Computer.- PEDPLO: The Pedigree Plot Program.- Cell Typing by Computer.- Unbiased Serum Analysis.- Selection of a Set of High-Quality Data for B Cell Antigen Analysis.- The Serological Analysis of the Data of the Ninth Histocompatibility Workshop.- Analysis of HLA-DR Typing sera Used in the Workshop Transplant Study.- Antigen Reports.- HLA-A1.- HLA-A2.- HLA-A3.- HLA-A11.- HLA-A23.- HLA-A24.- A9.3.- HLA-A25.- HLA-A26.- HLA-A28.- HLA-A29.- HLA-A30 HLA-A31.- HLA-A32.- HLA-Aw33.- HLA-Aw34.- HLA-Aw36.- HLA-Aw43.- HLA-Aw66.- TH.- HLA-B7.- HLA-B8.- HLA-B13.- HLA-B14: Definite Splitting into Bw64 (14.1) and Bw65 (14.2).- HLA-B18.- HLA-B27.- HLA-B35.- HLA-B37.- HLA-B38.- HLA-B39.- HLA-BW41.- HLA-BW.- HLA-B44.- HLA-B45.- HLA-BW46.- HLA-BW47.- HLA-BW48.- HLA-B49.- HLA-Bw50.- HLA-B51 and HLA-Bw52.- HLA-BW53.- HLA-BW54, HLA-BW55, and HLA-BW56.- HLA-BW57.- HLA-BW58.- HLA-Bw59.- HLA-BW60.- HLA-BW61.- HLA-Bw62 and Other Bw6-Associated Variants of B15.- HLA-Bw63 and Other Bw4-Associated Variants of B15.- HLA-Bw67.- HLA-Bw70, HLA-Bw71, and HLA-Bw72.- HLA-Bw73.- HLA-Bw4 and HLA-Bw6.- HLA-CWL.- HLA-CW2.- HLA-CW3.- HLA-CW4.- HLA-CW5.- HLA-CW6.- HLA-CW7.- HLA-CW8.- NEW HLA-C.- HLA-DR1.- HLA-DR2.- HLA-DR3.- HLA-DR4.- HLA-DR5 and Its Subtypes HLA-DRwl 1 and HLA-DRwl2.- HLA-DRW6 and Its Subgroups HLA-DRWL3 and HLA-DRWL4.- HLA-DR7.- HLA-DRW8.- HLA-DRW9.- HLA-DRWL0.- HLA-DRW52.- HLA-DRW53.- New HLA-DR.- HLA-DQWL.- HLA-DQW2.- HLA-DQW3.- Reports on Monoclonal Antibodies.- HLA-A, B, C Monoclonal Antibodies.- HLA-D Region Monoclonal Antibodies.- Special Serology Reports.- HLA-A, B, Interlocus Specificities.- Specificity of The Ninth Workshop Anti la Alloantisera As Assessed by The Direct Binding Assay.- HLA-DR, DQ, and DW Relationships.- HLA-DR, DQ, LB, and TA10 Specificities of Ninth Workshop Homozygous Typing Cells.- Cellular Part: Homozygous Typing Cells (HTC).- Definition of HLA-D with HTC.- Segregation Analysis (HTCS).- First Level Testing of HLA-DR4-Associated New HLA-D Specificities: DWL3 (DB3), DWL4 (LD40), DWL5 (DYT), and DKT2.- First Level Testing of DW6 HTC.- First Level Testing of DW7 HTC.- First Level Testing of DW8 HTC.- First Level Testing of HLA-D “Blank” HTC.- DNA Restriction Fragment Length Polymorphism of Some Ninth Workshop Homozygous Typing Cells Using a cDNA Probe Specific for DRß.- Cellular Part: Primed Lymphocyte Typing (PLT).- Genetic Analysis of HLA-D Region Products Defined by PLT.- Segregation Analysis of PLT Reagents in Families.- Median Stabilization of PLT Data for the Central Workshop Analysis.- Origin and Expansion of SB (DP)-Specific Reagents Characterized in the Ninth International Workshop.- Cellular Part: Cell-Mediated Lympholysis (CML).- CML: A Method for Cellular Typing.- Complement Polymorphisms.- The Second Complement Component, C2, in the Ninth Workshop.- Properdin Factor B.- C4 Polymorphism.- Genetics of HLA.- Analysis of MHC Recombinant Families.- Linkage Between HLA-A, C, B, Bf and DR Alleles: Haplotype Study of Healthy Families by Factorial Correspondence Analysis.- The Nature of Selection in the HLA Region Based on Population Data From the Ninth Workshop.- Population Analysis on the Basis of Deduced Haplotypes from Random Families.- Ninth International Histocompatibility Workshop Renal Transplant Study.- Disease Reports.- Insulin-Dependent Diabetes Mellitus.- HLA-DR3 and DR7-Negative Celiac Disease.- Leprosy.- Juvenile Chronic Arthritis, Pauciarticular Type.- A Family Study of Gold-Induced Nephropathy in Patients with Rheumatoid Arthritis.- Rheumatoid Arthritis.- D-Penicillamine-Induced Myasthenia Gravis.- HLA-B27-Negative Ankylosing Spondylitis.- Scleroderma: Possible Association with the C4 System - A Progress Report.- Beh?et’s Disease.- Kawasaki Disease (Mucocutaneous Lymph Node Syndrome).- Classical and AIDS Kaposi’s Sarcoma.- HLA and Familial Malignant Melanoma.- Hodgkin’s Disease.- Original Contributions.- Serology.- Human Histocompatibility Antigens in Malignant Tumors of Nonlymphoid Origin.- B27 Subtypes.- Segregation of DQ and DR: “Exceptions to the Rule”.- Characterization of a New Subset of B Cell Alloantigens.- Serologic Detection of New Polymorphisms on DQ Molecules Distinct from the DQw1, 2, and 3 Specificities.- Analysis of 9W Antisera Detecting DR4- and DR2-Associated Epitopes by Use of Anti-idiotypic Antibodies.- The HLA-D Region: Serology, Structure, Tissue Distribution, and Function of Human Class II Molecules and Their Antigenic Determinants.- Definition of MCI, a Novel HLA Determinant Associated with DR1 and DR4.- A Monoclonal Antibody (GH-3): “Non-orthodox” Anti-HLA-A3 or A11 Induced by a Lymph Node Extract from a Hodgkin’s Disease Patient.- Enhancing Monoclonal Antibodies Against HLA-Bw4 Molecules.- Spatial Localization of Allospecific HLA Class I Epitopes by Antibody Blocking Studies.- Analysis of Homozygous Typing Cells with Primed Lymphocytes and Monoclonal Antibodies Directed Against Polymorphic la Antigen Epitopes.- A Monoclonal Antibody Detects a New Antigenic Determinant Shared by DR1 and DR4/Dw4 Molecules.- Serological Analysis of Two Monoclonal Antibodies: One Detecting an DRw53 Supertypic Determinant and One Detecting a New Supertypic Determinant Related to HLA-DR7.- Study of Monoclonal Antibodies to the HLA-D Region Products DQW1 and DRw52.- Characterisation of the HLA-D Region DQw3 Specificity Using the Monoclonal Antibodies 2HB6 and IVD12.- Idiotypic Analysis of Anti-Human MHC Class II Monoclonal Antibodies by Syngeneic Anti-Idiotypes.- Comparison of Human-Human and Human-Mouse Hybridoma Systems for the Production of Alloreactive Human Monoclonal Antibodies.- Crossreactivity of Monoclonal Anti-HLA Antibodies with Rhesus Monkey Lymphocytes.- A Simple and Rapid Procedure for Purification of Human Dendritic Cells From Peripheral Blood.- HLA-A, B, C Typing Using Serum.- Definition of Two Monocyte-Specific Antigens, One of Which Correlates with the 9 a Antigen.- Anti-Idiotypic Antibodies in Women with Successful Pregnancy.- T-Cell Alloantigens.- Class I MHC-Linked Determinants Expressed on Activated T Cells.- Alloantibodies to PHA-Activated Lymphocytes Detect Human QA-Like Antigens.- T Cell System A in Humans is Probably Equivalent to Qa or Tla in Mice.- New Determinants Expressed on Activated Lymphocytes and on Human Acute Lymphoblastic Leukemia Cells Closely Linked to Conventional HLA-A Antigens.- Cellular Definition of HLA Antigens.- Analysis of DP Region Products by T Cells and Monoclonal Antibodies:Blocking of DP-Specific Proliferation and Cell-Mediated Cytotoxicity.- Typing for DP-like Determinants.- LB-Q1 and LB-Q2: Population Genetics in Dutch Caucasoids and Inhibition Studies with Monoclonal Antibodies.- Allelic Class II Determinants Defined by PLT Typing.- HLA-D and DR in Different Populations.- Private Specificities of Human IA-Like Molecules Detected by T Cell Lines.- PLT Analysis of D Region Complexity by Cloned Cells: A New Non-DP Antigen.- Correlation Between PLT and CML Specificity of Alloreactive TCell Clones.- Heterogeneity of DR5-Associated Alloantigens Detected by Human T Lymphocyte Clones.- Heterogeneity of HLA-B7 as Detected by Cytotoxic T Cell Clones.- Analysis of Cytolytic Clones Directed at Class I and Class II Antigens Using HLA Loss Mutants of a Lymphoblastoid Cell Line.- HLA Mutants of Lymphoblastoid Cell Lines: Generation of New Mutants and Analysis by Southern Blotting.- Mutant Cell Lines as Means of Resolving HLA Gene Products.- Human T Cell Clone Inhibition by Distinct Monoclonal Anti-HLA-DR Antibodies.- Variation in the Epitopes on the HLA-A2 Molecule as Recognized by HLA-A2 Restricted and Alloimmune HLA-A2-Specific Cytotoxic T Lymphocytes.- Cloned Cytotoxic T Cells Which May Define a Minor Transplantation Antigen and a Variant of the HLA-B8 Molecule.- Construction and Expansion of CTLs for HLA Typing: Definition of B44 Subtypes by Cellular Typing.- Frequencies of Proliferative and Cytotoxic Precursor T Cells During a Course of Active Immunization as Analysed by Limiting Dilution.- HLA Class II Alloantigens Defined by Cytotoxic T Cell Clones and Monoclonal Antibodies.- Biochemistry of HLA Antigen.- Structural Analysis of the Polymorphism of HLA Class I Antigens.- Molecular and Functional Analysis of Class II Molecules Characteristic to HLA-Dw2 and Dwl2.- Two-dimensional Gel Analysis of DR2 and DQwl Molecules Isolated from Dw2 and Dwl2 Homozygous Cell Lines.- Separation of Three Human B-Cell Alloantigens, DR4, DRw53, and DQw3 (TB21), by Two-dimensional Gel Electrophoresis: Comparison of Alloantibodies and Monoclonal Antibodies.- Serological and Structural Heterogeneity of HLA-DR4 Alloantigens.- Molecular Polymorphism of DR and DQ Products.- Structural Polymorphism in DQw3 Light Chains.- Molecular Dissection of DRw6.- Heterogeneity of HLA Class II Gene Products as Studied in a Family by Sequential Immunoprecipitation.- A Supertypic DRw53 Determinant is Carried on the HLA-DR Subset of Class II Molecules on HLA-DR7 Cell Lines n.- The Molecular Complexity of DR7-Associated la Molecules.- Alloantisera and Monoclonal Antibodies Which Appear to Define the Same la Allospecificity in Population Studies Do Not Detect the Same la Molecules in Biochemical Studies.- The Polymorphism of DQ (DC) Molecules.- Comparison of Supertypic Specificities by Cytotoxicity and by Radioimmunoassay in Segregating Families.- HLA-FA: A Non-DR, Non-DQ HLA Class II Product.- Hybrid HLA-DQ Antigens: Molecular Expression.- Nonassociated HLA-DR ? and ? Chains: Molecular Detection and Differential Cellular Expression.- The Expression of HLA-DR, DQ and DP Antigens on the Surface of Lymphocytes as Assessed by 2-D Polyacrylamide Gel Analysis of Immunoprecipitates.- Preferential Increase of Expression and Release of DQ Molecules in Human Cells Treated with Interferons.- Differential Molecular Expression of HLA-DR and HLA DQ Antigens in Leukemic Cells.- Analysis of HLA Genes at the DNA Level.- HLA Class I Gene Typing with an HLA-B-Specific DNA Probe.- A Study of HLA-B-Locus Polymorphism with a Specific Hybridization Probe.- HLA Gene Polymorphisms: Class I.- HLA Gene Polymorphism: Class II.- Association of Class I and Class II MHC Restriction Fragment Polymorphism with HLA-Related Diseases.- Cloning and Expression of the Gene Encoding HLA-A11.- Isolation and Characterization of the cDNA Clones and the Genomic Clones of the HLA Class II Antigen Heavy Chains.- DNA Polymorphism of HLA-DR? and HLA-DP? Genes.- Molecular Complexity of the HLA-DR, DQ, and DP Genes and Genotypic Split of HLA-DR Serological Specificities by “DNA Typing”.- HLA Class II Polymorphism: Restriction Fragment Patterns Correlated to Ninth Workshop Serology and Function.- HLA-DRw6: A Molecular Approach.- Molecular Analysis of HLA: Haplotype-Specific DNA Hybridization Patterns Using Class II cDNA Probes.- Analysis and Segregation of HLA-DR by DNA Typing: Correlation with Supertypic Specificities.- Recombinant DNA Technology: Its Use in the Study of HLA.- HLA-DR and DQ, Studied with Genomic Blotting, in Diabetic Families and Transplant Donor-Recipient Pairs.- DNA Restriction Fragment Length Polymorphism of the Human Class II Genes as Analyzed by Southern Blotting Technique.- Mouse L Cells Expressing Human HLA-DR Antigens After Transfection with Class II Genes Do Not Stimulate Human T Lymphocytes.- Modification of Immunogenicity of Leukaemic Cells by DNA Mediated Gene Transfer.- Genetics of HLA.- Precise Location of HLA Genes on Chromosome 6.- A Structural Locus for Coagulation Factor XIIIA (Fl3A) Is Located Distal to HLA on the Short Arm of Chromosome 6 in Man.- The Selective Origin of Linkage Disequilibrium in the HLA Region.- HLA-A, B Genes in the World and the Effect of Climate.- Glyoxalase I (GLO I) Phenotyping by Isoelectric Focusing.- Complement Polymorphisms.- C4 Haplotypes with Duplicated C4A or C4B: Frequency and Associations with Bf, C2, and HLA-A, B, C, DR Alleles with Special Reference to the Duplication C4B1,2.- Gene Duplication of C4A in the Lancaster County, Pennsylvania, Old Order Amish: C4A*2A*3 is in Coupling with HLA A3, Cw4, B35, BfF, DR1, GL02.- Distinct Complotypes Are Associated with HLA-B14 Subgroups.- Bf Polymorphism Studied by Isoelectrofocusing.- >Function of HLA Gene Products.- Genetic Control of HLA-Linked Immune Responsiveness to Synthetic Polypeptides in Healthy Individuals and Patients with Autoimmune Diseases.- HLA-Linked Immune Suppression Genes: A Mechanism for the Statistical Association Between HLA and Disease.- Effects of Anti-DQ (MB) and Anti-DR Monoclonal Antibodies on In Vitro Immune Responses.- Individual Differences in the In Vitro (CTC) Immune Response to HLA Antigens.- HLA-Linked Gene Regulation of the Immune Response to Nitrofurantoin-Albumin.- Phenotype and Specificity of MLR-Generated Suppressor Cells.- Alloproliferative T4+ T8- Human T Cell Clones with Suppressive, Not Helper, Function.- Relationship Between the OKT Phenotype of Alloreactive Human T Cell Clones and Their Specificity for HLA Class II Antigens.- Functional Heterogeneity of Human T Cell Responses to Class I and Class IIMHC Antigens.- Restriction of Human Influenza A Virus-Specific T Cell Clones by HTC-Defined Subtypes of HLA-Dw6.- Antigen-Specific T Cell Clones Restricted by DR, DQ, or DP Class II HLA Molecules.- HLA-DR Typing by Restriction Specificity. A Functional Approach Using PPD-Specific CTLs and Antigen Presenting Monocytes.- Cytotoxic T Cells Generated During GvHD Can Detect Minor Histocompatibility Antigens in an HLA-Restricted Fashion.- Clonal Distribution of Human T Cells Recognizing PPD in the Context of Each of Two Distinct la Molecules.- Function of DRw52 and LB-Q1 in Antigen Presentation.- Subdivision of DRw6 by Influenza-Specific Proliferative Cloned Cell Lines.- Human T Cell-Mø Collaboration Across Allogeneic Barrier.- Expression of HLA-DQ Molecules on Human Monocytes: Identification of Two Phenotypically Different Monocyte Populations with Distinct Accessory Cell Function.- Differential Expression of the HLA-DQ Antigens on Acute Leukaemic Blasts.- Expression of HLA Class II Molecules on Human Monocytes and Dendritic Cells.- Absence of DQwl on Monocytes Depending on the DR Antigens Expressed.- Interaction Between HLA Class I Antigens and ?-Endorphin.- The Major Histocompatibility Complex as an Antibiosenescent System.- HLA and Disease.- Defective Expression of HLA-D-Region Determinants in Children with Congenital Agammaglobulinemia and Malabsorption: A New Syndrome.- Defect of Expression of MHC Genes Responsible for an Abnormal HLA Class I Phenotype and the Class II Negative Phenotype of Lymphocytes from Patients with Combined Immunodeficiency.- Inheritance and Possible Coinheritance of HLA-Linked Susceptibilities to Insulin-Dependent Diabetes Mellitus, Autoimmune Thyroid Diseases, and Rheumatoid Arthritis.- Genetic Polymorphism of the Fourth Component of Complement (C4)- and Type I Insulin-Dependent Diabetes.- Presence of Thyroid-Stimulating Immunoglobulins (TSI) in DR3 Positive Normal Individuals.- Three Different HLA Associations in the Three Types of 21-Hydroxylase Congenital Adrenal Hyperplasia.- Distinct HLA-B Antigen Associations for the Salt-Wasting and Simple Virilizing Forms of Congenital Adrenal Hyperplasia Due to 21 -Hydroxylase Deficiency.- Defect of Ferritin Secretion in HLA-A3 Subjects and in Idiopathic Hemochromatosis.- Immunogenetic Analysis of Leprosy in Japan.- Affected Sib Methods.- Genetic Interrelationship Amongst HLA-Associated Diseases.- Is the Lod Score Method Reliable in HLA-Associated Diseases?.- HLA-DR, Gm Allotypes and Sex as Risk Factors for Celiac Disease.- Transplantation.- The Relative Importance of MLC and HLA-DR Compatibility in Cadaver Kidney Transplantation.- Long-Term Follow-Up of London Transplant Group (LTG) Renal Transplant Patients.- The Influence of HLA-A, B Compatibility on Cadaver Donor Renal Transplantation in SEOPF.- Donor-Specific Blood Transfusion and Renal Graft Survival: A 3-Year Experience in Pediatrics.- Marrow Transplantation from Donors Other Than HLA Genotypically Identical Siblings: The Immunogenetics of Acute Graft Versus Host Disease.- Immunological Investigation of Patients Treated for Leukaemia by Bone Marrow Transplantation (BMT).- Chimerism Following Fetal Liver and Thymus Transplantation.- Annex.- Reference Tables of Two-Locus Haplotype Frequencies for All MHC Marker Loci.- Reference Tables of Three-Locus Haplotype Frequencies and Delta Values in Caucasians, Orientals, and Negroids.- Index of Authors.