Histiocytic Disorders

ISBN-13: 9783319596310 / Angielski / Twarda / 2017 / 392 str.

Oussama Abla; Gritta Janka

Opis

This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.
Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Spis treści

Section I Pathology of Histiocytic Disorders

Chapter 1 Pathology of Histiocytic Disorders and Neoplasms and Related Disorders

Jennifer Picarsic, Ronald Jaffe

Section II : Langerhans Cell Histiocytosis (LCH)

Chapter 2 Biology and Genomics of LCH and Related Disorders

Barrett J. Rollins

Chapter 3 Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

Etai Adam, Rima Jubran, Sheila Weitzman

Chapter 4 Central Nervous System Langerhans Cell Histiocytosis

Milen Minkov, Jennifer Picarsic, Karoly Lakatos

Chapter 5 First-line Treatment of Pediatric Langerhans Cell Histiocytosis

Carlos Rodriguez-Galindo, Cor van den Bos

Chapter 6 Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children

Oussama Abla, Carlos Rodriguez-Galindo, Paul Veys

Chapter 7 Adult Langerhans Cell Histiocytosis

Michael Girschikofsky, Abdellatif Tazi

Chapter 8 Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy 

Vasanta Nanduri, Lilibeth R. Torno, Riccardo Haupt

Section III : Hemophagocytic Lymphohistiocytosis (HLH)

Chapter 9 Classification, Clinical Manifestations and Diagnostics of HLH

Jana Pachlopnik Schmid, Benjamin Volkmer, Stephan Ehl

Chapter 10 CNS involvement in HLH (CNS-HLH)

AnnaCarin Horne, Karin Beutel

Chapter 11 Genetics and Pathogenesis of Haemophagocytic Lymphohistiocytosis

Geneviève de Saint Basile1, Despina Moshous, Alain Fischer

Chapter 12 Hemophagocytic Lymphohistiocytosis  Associated with Malignancies and with Epstein Barr Virus

Chapter 13 Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)

Alexei A. Grom, AnnaCarin Horne, Fabrizio De Benedetti

Chapter 14 Treatment of Newly Diagnosed HLH and Refractory Disease 

Jan-Inge Henter, Rebecca A Marsh, Tatiana von Bahr Greenwood

Chapter 15 Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic Lymphohistiocytosis

K. Scott Baker, Michael B. Jordan

Chapter 16 HLH in Adults

Paul La Rosée, Rafal Machowicz

Section IV Rare Histiocytic Disorders: Non-Langerhans Cell Histocytosis

Chapter 17 Juvenile Xanthogranuloma and Related Non-LCH Disorders

Francesco Ceppi, Oussama Abla

Chapter 18 Erdheim-Chester Disease 

Eli L. Diamond, Benjamin H. Durham

Chapter 19 Rosai-Dorfman Disease

Oussama Abla, Jennifer Picarsic

Chapter 20 Malignant Histiocytoses

Eric Jacobsen, Oussama Abla, Johannes Visser

O autorze

Oussama Abla, MD

Chair, Rare Histiocytoses Steering Committee- Histiocyte Society, Associate Professor of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, 

Canada

Gritta Janka, MD, PhD

Chair, HLH Steering Committee, Histiocyte Society, Professor emeritus of Pediatrics, University Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany