Histamine in Inflammation

ISBN-13: 9781441980557 / Angielski / Twarda / 2010 / 143 str.

Robin L. Thurmond

Opis

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term "antihistamine" has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area--inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Spis treści

1. One Hundred Years of Histamine Research Katherine Figueroa and Nigel ShankleyAbstractIntroductionExploring the Physiological Effects of HistamineThe First AntihistaminesPharmacological Definition of Histamine H1 and H2 ReceptorsPharmacological Definition of the Histamine H3 ReceptorPharmacological Definition of the Histamine H4 ReceptorThe Molecular Biological Characterization of Histamine ReceptorsAlternative Intracellular Signaling of Histamine ReceptorsGenerations of Histamine Targeted Genetically Modified MiceConclusion2. Molecular Pharmacology of the Four Histamine ReceptorsGerold Bongers, Iwan de Esch and Rob LeursAbstractThe Discovery of the Four Histamine Receptors: An Historical OverviewHistamine Receptors, Signal Transduction and Their LigandsThe Histamine H1 Receptor and Its LigandsThe Histamine H2 Receptor and Its LigandsThe Histamine H3 Receptor and Its LigandsThe Histamine H4 Receptor and Its LigandsConclusion3. Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient MiceHiroshi OhtsuAbstractIntroductionHDC Transcriptional RegulationEpigenetic Regulation of HDC Gene Expressionl?Histidine Decarboxylase Gene Knockout MiceHistamine and ImmunityHistamine in Wound HealingHistamine in MalariaHistamine in Crohn’sDiseaseHistamine in Allergic Bronchial AsthmaHistamine in Systemic Anaphylaxis ModelHistamine in AtherosclerosisHistamine Uptake into and Release from Histamine Producing CellsConclusion4. Histamine in Allergic Rhinitis Thomas Taylor?ClarkAbstractIntroductionHistamine and the Early Phase Response in Allergic RhinitisH1 Receptors: Sensory Nerve Activation and Central ReflexesH1 Receptors and the Nasal VasculatureOther Histamine Receptors in the Early Phase ResponseHistamine Receptors and Immune ModulationConclusion5. The Role of Histamine in Ocular Allergy Masaharu Ohbayashi, Bita Manzouri, Kei Morohoshi, Ken Fukuda and Santa J.OnoAbstractIntroductionClinical Manifestations of Ocular AllergyCurrent Treatments for Ocular AllergyAllergic Responses in the ConjunctivaMast Cells in the ConjunctivaHistamine in the ConjunctivaHistamine and the Conjunctival BarrierHistamine Receptors in the ConjunctivaTissue?Specific Roles of Histamine ReceptorsConclusion6. The Role of Histamine in Asthma Paul J. Dunford and Stephen T. HolgateAbstractIntroductionHistamine in the Asthmatic AirwayPhysiologic Role for Histamine in Lung and AsthmaImmunological Modulation by

O autorze

Robin L. Thurmond, PhD is a Compound Development Team Leader with the Clinical Research group at Johnson & Johnson Pharmaceutical Research & Development in La Jolla, California. Prior to that he was a Research Fellow with the Immunology Drug Discovery group at the same site. He received his BA in Chemistry from the University of Virginia and his PhD in Biochemistry from the University of Arizona. Dr. Thurmond studied membrane biophysics at the University of Arizona and worked on the molecular aspects of rhodopsin function during his postdoctoral training at the Massachusetts Institute of Technology with Dr. Gobind Khorana. He began his career with Johnson & Johnson in 1996 at the RW Johnson Pharmaceutical Research Institute in Raritan, New Jersey, and has been with Johnson & Johnson for over 14 years. Dr. Thurmond currently resides in San Diego, California.