Highly Selective Neurotoxins: Basic and Clinical Applications

ISBN-13: 9780896034655 / Angielski / Twarda / 1997 / 404 str.

Richard M. Kostrzewa

Opis

Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.

Spis treści

6-Hydroxydopamine and Related Catecholaminergic Neurotoxins: Molecular Mechanisms, C. L. Blank, R. J. Lewis, and R. E. Lehr. The Use of Neurotoxins to Lesion Catecholamine-Containing Neurons to Model Clinical Disorders: Approach for Defining Adaptive Neural Mechanisms and Role of Neurotrophic Factors in Brain, C. R. Breese and G. R. Breese. 6-Hydroxydopamine as a Tool for Studying Catecholamines in Adult Animals: Lessons from the Neostriatum, M. J. Zigmond and K. A. Keefe. 6-Hydroxydopa, a Catecholamine Neurotoxin and Endogenous Excitotoxin at Non-NMDA Receptors, R. M. Kostrzewa. 2-Chloroethylamines (DSP4 and Xylamine): Toxic Actions on Noradrenergic Neurons, G. Jaim-Etcheverry. MPTP: A Dopaminergic Neurotoxin, J. E. Royland and J. W. Langston. Haloperidol-Derived Pyridinium Metabolites: Structural and Toxicological Relationships to MPP+-Like Neurotoxins, C. J. Van der Schyf, E. Usuki, S. M. Pond, and N. Castagnoli, Jr. The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula, G. Ellison. Evidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds, R. Lew, J. E. Malberg, G. A. Ricuarte, and L. S. Seiden. Molecular Mechanisms of Action of 5,6- and 5,7-Dihydroxytryptamine, T. Tabatabaie and G. Dryhurst. Use of 5,6- and 5,7-Dihydroxytryptamine to Lesion Serotonin Neurons, M. R. Pranzatelli. Selective Cholinergic Neurotoxins: AF64A and 192-IgG-Saporin, T. J. Walsh and P. E. Potter. Glutamatergic Receptor Agonists and Brain Pathology, E. M. Urbanska, A. Dekundy, Z. Kleinrok, W. A. Turski, and S. J. Czuczwar. Neurotoxicity of NMDA Receptor Antagonists, S. Rajdev and F. R. Sharp. Toxic Vanilloids, A. Szallasi. Index.

Blurb

In Highly Selective Neurotoxins, experienced experimentalists critically review and evaluate the most common and important neurotoxins used today to precisely destroy selected neurons. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on its use and its clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants.

Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins. Its authoritative coverage of the newest findings on experimentally important neurotoxins makes their proper use and their limitations clear and practical from both experimental and theoretical points of view.