High Throughput Screening for Novel Anti-Inflammatories

ISBN-13: 9783764359126 / Angielski / Twarda / 2000 / 258 str.

Michael Kahn; M. Kahn; Michael Kahn

Opis

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with info rmation from genomics, proteomics, computation and pharmacokinetics be fore dramatic increases in the drug discovery/development processes ca n be achieved. The chapters in this book represent the state of the ar t regarding the integration of combinatorial chemistry and HTS in conn ection with anti-inflammatory targets. Obviously, there is much work t o be done beyond what is described in this text, nevertheless, it shou ld set the stage for creative thinking among scientists of many discip lines for the accomplishment of our ultimate goals in treating inflamm atory diseases.

Spis treści

Solid phase synthesis: Applications to combinatorial libraries.- Proteasome inhibitors.- Caspase-1 (ICE) and other caspases as drug discovery targets: Opportunities and progress.- Elastase inhibitors.- A high throughput assay for the TNF converting enzyme.- Tryptase inhibitors.- Selectin antagonists.- Cell adhesion integrins as pharmaceutical targets.- Inhibitors of the MAPK pathway.- Inhibition of NF-?B.- IL-1 antagonist discovery.- Phosphodiesterase inhibitors for respiratory diseases.