High-Risk Breast Cancer: Therapy

ISBN-13: 9783642747304 / Angielski / Miękka / 2011 / 517 str.

Joseph Ragaz; Irving M. Ariel

Opis

The many advances in breast cancer research, as well as the large quantity of published material, make it very difficult to gain insight into the global aspects of cancer management. To follow and understand all the new developments is becoming a major challenge. For this reason, the editors decided to bring together a group of top researchers in breast cancer to provide a comprehensive, yet readable conceptual review of the state of the art of breast cancer diagnosis and therapy. The proposal to focus the review on the quantitative assessment of the risk at diagnosis, the determination of which may permit selective therapies for individual patients, was met with enthusiastic approval, resulting in the present volume with contributions by the leading investigators in the field. While the volume relating to diagnosis, published re cently, focused on efforts leading to refinement at diagnosis of risk criteria sensitive enough to reliably distinguish the low- and high-risk categories, the second volume, by provid ing a review of the main problems and results of therapy given to high-risk patients, can be considered as a continua tion of the first book. A refined risk assessment at diagnosis and the application of the most suitable treatments to well selected individuals are the most important steps towards avoiding the present worrisome reality of overtreating the low risk and undertreating the high-risk patients. The first few chapters of the present volume offer an insight into the general management of early breast cancer."

Spis treści

Therapeutic Highlights of High-Risk Breast Cancer: Comments Related to Surgery, Radiotherapy, and Hormonal Therapy.- General.- Metastasis as a Determinant of Risk in Breast Cancer.- Comments on Clinical and Therapeutic Aspects of High-Risk Breast Cancer.- Role of Preoperative Therapy in High-Risk Breast Cancer: Review.- Surgery.- The Role of Surgery in the Treatment of Breast Cancer: Historical Review and Current Status.- High-Risk Breast Cancer: Bilaterality.- Conservative Surgery and Radiation Therapy for Early Breast Cancer.- Radiotherapy.- The Role of Radiation Therapy in High-Risk Breast Cancer.- Hormonal Therapy.- The Role of Prolonged Antihormonal Treatment of Breast Cancer: A Strategy for Adjuvant Therapy.- Adjuvant Endocrine Therapy: Its Role in Primary Breast Cancer.- Chemotherapy—General.- Therapeutic Highlights of High-Risk Breast Cancer: Comments Related to Adjuvant Chemotherapy, Its Intensity, Duration, and Quality of Life.- Dose Intensity of Chemotherapy in High-Risk Breast Cancer.- Therapy—Adjuvant.- Trials of Adjuvant Chemotherapy for Operable Breast Cancer.- Adjuvant Chemotherapy Programs in Node-Negative Breast Cancer.- Adjuvant Chemotherapy of High-Risk Postmenopausal Breast Cancer.- Chemotherapy—Metastatic.- Intensive Treatment Considerations in Breast Cancer.- Anthracyclines and Anthracenediones in the Management of Breast Cancer.- Inflammatory Breast Cancer.- Inflammatory Breast Cancer.- Inflammatory Breast Carcinoma: The Experience of the Centre Jean Perrin.- What to Expect from Deep Cutaneous Biopsies in Inflammatory Breast Carcinoma.- Stage III Breast Cancer.- Locally Advanced Breast Cancer.- Locally Advanced Breast Cancer: A Review including the M.D. Anderson Experience.- Locally Advanced Breast Cancer: The National Cancer Institute Experience.- Autologous Bone Marrow Transplantation.- Dose Intensification Using High-Dose Combination Alkylating Agents and Autologous Bone Marrow Support in the Treatment of Primary and Metastatic Breast Cancer: A Review of the Duke Bone Marrow Transplantation Program Experience.- High-Dose Chemotherapy in Breast Cancer.- Therapeutic Aspects of Tumor Biology Research.- Therapeutic Implications of Recent Growth Factor Research.- Summary.- Future and Developmental Aspects of High-Risk Breast Cancer Therapy.