Heterogeneity of Alzheimer's Disease

ISBN-13: 9783642467783 / Angielski / Miękka / 2012 / 189 str.

Francois Boller; F. Forette; Z. S. Khachaturian

Opis

The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.

Spis treści

An Overview of Scientific Issues Associated with the Heterogeneity of Alzheimer’s Disease.- A Comparison of Clinical Outcome and Survival in Various Forms of Alzheimer’s Disease.- Prognostic Implications of Symptomatic Behaviors in Alzheimer’s Disease.- Heterogeneous Disappearance of Knowledge in Alzheimer’s Disease.- Neuropsychological Aspects of Alzheimer’s Disease: Evidence for Inter- and Intra-Function Heterogeneity.- Primary Progressive Aphasia: Sharpening the Focus on a Clinical Syndrome.- Therapeutic Drug Trials and Heterogeneity of Alzheimer’s Disease.- Pro and Con for Heterogeneity of Alzheimer’s Disease: A View from an Epidemiologist.- Heterogeneity in Familial Alzheimer’s Disease.- Molecular Genetic Evidence for Etiologic Heterogeneity of Alzheimer’s Disease.- Alzheimer’s Disease: many Aetiologies; one Pathogenesis.- Locus Heterogeneity of Alzheimer’s Disease.- Familial Alzheimer’s Disease in Germans from Russia: A Model of Genetic Heterogeneity in Alzheimer’s Disease.- Protein Phosphorylation Regulates Processing of the Alzheimer ?/A4-Amyloid Precursor Protein.- Alzheimer’s Disease and Neuroanatomy: Hypotheses and Proposals.- Distribution of Tau-PHF in Brodmann Areas Reveals a Heterogeneity of the Degenerating Process in Rostro-Caudal Regions and as a Function of Age.- Alzheimer’s Disease and Age-Related Pathology in Diffuse Lewy Body Disease.