Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

ISBN-13: 9783642273391 / Angielski / Twarda / 2013 / 346 str.

Ralf Bartenschlager

Opis

Chronic liver disease caused by infections with the hepatitis C virus (HCV) is a silent epidemic. Primary infection is often asymptomatic and therefore diagnosed in the majority of cases only at a stage of advanced liver damage such as liver fibrosis, cirrhosis or even hepatocellular carcinoma. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances.

Spis treści

The Origin of Hepatitis C Virus

Peter Simmonds

 

Cell Culture Systems for Hepatitis C Virus

Eike Steinmann and Thomas Pietschmann

 

Animal Models for Hepatitis C

Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss

 

Hepatitis C Virus Entry

Mirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert

 

Hepatitis C Virus Proteins: From Structure to Function

Darius Moradpour and François Penin

 

Hepatitis C Virus RNA Translation

Michael Niepmann

 

Hepatitis C Virus RNA Replication

Volker Lohmann

 

Virion Assembly and Release

Brett D. Lindenbach

 

Innate Immune Responses to Hepatitis C Virus

John W. Schoggins and Charles M. Rice

 

Adaptive Immune Responses in Hepatitis C Virus Infection

Christoph Neumann-Haefelin and Robert Thimme

 

Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

Daisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon

 

Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco

 

Treatment of Chronic Hepatitis C: Current and Future

Jean-Michel Pawlotsky

Blurb

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.