Heparinase and low molecular weight heparins as antitumor agents

ISBN-13: 9783659852169 / Angielski / Miękka / 2016 / 60 str.

Sahira Nsayef Muslim; Israa M.S. Abd Ali AL-Kadmy; Alaa N. Mohammed Ali Al-Khfajy

Opis

Heparan sulfate and chondroitin sulfate, play a key role in the extracellular matrix. Heparin is an acidic polysaccharide, characterized by a disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages.Heparin is heterogeneous due to the varying degree of modification of the functional groups in the disaccharide unit. Heparin may be hydrolyzed with acid only under vigorous condition which results in considerable caramelization, especially of the glucoronic acid and extensive splitting of heparin.Thus, the product are mono(or) disaccharides from which all the sulphated groups are removed.

O autorze

Dr. Sahira Nsayef Muslim received PHD in microbiology- Biotechnology Title: " Biochemical and genetic studies on hemolysin produced by Aeromonas hydrophila isolated from diarrheal patients and from surface water"Coll. Sci. - Mustansiryia university- 2005.