Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist

ISBN-13: 9783319874838 / Angielski / Miękka / 2019 / 460 str.

Valerie I. Brown

Spis treści

Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)

1. Introduction

Valerie I. Brown

2. Historical Overview of Pediatric HSCT 

Valerie I. Brown

3. Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT)

Valerie I. Brown

Part II. Topics Related to the Pre- HSCT Period

4. Pretransplantation: Indications and Timing

Alicia McFarren and Michael A. Pulsipher

5. Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia

Abdel-Azim and Michael A. Pulsipher

6. HSCT Recipient Pretransplantation Evaluation 

Carrie Eichelberger and Valerie I. Brown

7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT 

Malika Kapadia and Robert Greiner 

8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation 

William Ferguson and Aleksander Babic

9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale 

Carrie Kitko, Katie Gatwood, James Connelly

Part III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods

10. Engraftment and Chimerism 

Valerie I. Brown

11. Graft Failure 

Valerie I. Brown

12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome 

Mala K. Talekar and Jason L. Freedman

13. Nutrition in the Peri-HSCT Period 

Arun Gurunathan, Judy Bailer, Jason L. Freedman

14. Mucositis and Pain in the Peri- HSCT Period 

Arun Gurunathan, Neil S. Patel, Jason L. Freedman

15. Hepatoxicity in the Peri- HSCT Period 

Valerie I. Brown

16. Renal Toxicities in the Peri-HSCT Period

Malika Kapadia, Terry Shapiro and Robert Greiner

17. Infectious Complications and HSCT 

Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman

18. Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment

Karen L. Bride, Neil S. Patel, Jason L. Freedman

Part IV. The Late Post- HSCT Period (> 100 Days)

19. Chronic GVHD 

Terry Wikle Shapiro, Malika Kapadia

20. Hematologic Complications Associated with HSCT 

Mala K. Talekar and Timothy Olson

21. Pulmonary Complications Associated with HSCT 

Malika Kapadia and Terry Shapiro

22. Renal Complications Associated with HSCT 

Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin

23. Cardiac Complications Associated with HSCT 

Valerie I. Brown

24. Neurologic and Sensory Complications Associated with HSCT 

Valerie I. Brown

25. HSCT-Associated Complications of the Skin, Hair and Nails 

Valerie I. Brown

Part V: Life After HSCT

26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation 

Mala K. Talekar and Timothy Olsen

27. Life After HSCT: Survivorship and Long-Term Issues 

Smita Dandekar

Part VI. Pharmacologic-Related Issues of Pediatric HSCT

28. Medications commonly Used in Pediatric HSCT 

Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood

O autorze

Valerie I. Brown, MD, PhD

Director, Experimental Therapeutics, Pediatric Hematology/Oncology

Director, Pediatric Hematology/Oncology Fellowship Program

Penn State Milton S. Hershey Medical Center and Children’s Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA

Blurb

This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.

Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.