Helicobacter Pylori: Basic Mechanisms to Clinical Cure 1996

ISBN-13: 9789401072991 / Angielski / Miękka / 2011 / 420 str.

R. H. Hunt; G. N. Tytgat

Opis

The impact of Helicobacter pylori on basic science and the clinical management of patients with the complications of this infection is bewildering. The explosion of new information both in the laboratory and at the bedside has progressed at an unprecedented rate. Our main objective in furthering this progress has been to integrate this new information and organize a series of top quality presentations and discussions between investigators and clinicians on all aspects of H. pylori research and to review the current position and future research directions. To that end, the second meeting Helicobacter pylori: Basic Mechanisms to Clinical Cure was organized in June 1996 in Ottawa, Canada, following the successful format of the first such meeting held in Amelia Island, Florida, in 1993. The meeting again focused on all timely aspects of H. pylori research. Internationally renowned basic and clinical scientists, all experts in their respective fields, explored in depth the spectrum of H. pylori infection and the related complications of gastritis, peptic ulcer, gastric cancer and lymphoma. The presentations covered: the genetic heterogeneity of the organism, including the expression of virulence factors determined by the genetic pathogenicity island; the intricate cascade of chemokines and cytokines leading to mucosal inflammation; the complexities of the mucosal immune response, favoring a slight Th1 over Th2 lymphocyte imbalance; the fundamental issue of the apparent paradox of the induction of both apoptosis and epithelial hyperproliferation; the pathophysiological consequences of gastric mucosal inflammation with respect to the elevation of gastrin and the acid secretory response; the mechanisms leading to peptic ulcer disease, gastric carcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma; the established and novel therapeutic approaches to eradication and finally the prospects for successful therapeutic and preventative vaccination. The comprehensive manuscripts in this book of the proceedings of the meeting reflect the most up-to-date information and state of the art approaches to research and management of H. pylori infection and will provide an invaluable reference source.

Spis treści

Preface. 1. Mixed gastric infections and infection with other Helicobacter species; S.L. Hazell. 2. In vivo studies of emergent issues in gastric Helicobacter pathogenesis and epidemiology; J.G. Fox. 3. Genetic bases for heterogeneity of Helicobacter pylori; M.J. Blaser. 4. Mobilis in mobile: Unexpected flexibility and quantum leaps in the Helicobacter pylori genome; A. Covacci. 5. Effect of gastric acid on Helicobacter pylori ecology; A. Lee, et al. 6. Helicobacter pylori and the gastric environment; G. Sachs, et al. 7. P type ion motive ATPases of Helicobacter pylori; K. Melchers, et al. 8. Which is the most important factor in duodenal ulcer pathogenesis: the strain of Helicobacter pylori or the host? D.Y. Graham, et al. 9. The effect of Helicobacter pylori on the surface hydrophobicity and phospholipid composition of the gastric mucosa; L.M. Lichtenberger. 10. Mediators of inflammation in Helicobacter pylori infection; K. Bodger, J.E. Crabtree. 11. Effects of abnormalities of gastrin and somatostatin in Helicobacter pylori infection on acid secretion; J. Calam, et al. 12. Helicobacter pylori gastritis and gastric acid secretory function - an integrated approach; K.E.L. McColl, et al. 13. Nitric oxide, bacteria and ulcer healing; S.N. Elliott, J.L. Wallace. 14. Effects of infection with Helicobacter pylori on gastric epithelium; S.E. Crowe, et al. 15. Is the TH1/TH2 lymphocyte balance upset by Helicobacter pylori infection; P.B. Ernst, et al. 16. What determines the vigour of the immune response to Helicobacter pylori? K. Croitoru, D. Snider. 17. Theories of vaccination for Helicobacter pylori; W.F. Doe. 18. Vaccines for the treatment and prevention of Helicobacter pylori infection; I. Corthésy-Theulaz, et al. 19. The epithelial changes associated with Helicobacter pylori infection: the biology of gastric and intestinal metaplasia; N. Wright. 20. Cell regulation, differentiation and their sequelae in the Helicobacter pylori inflamed and eradicated stomach; R.H. Riddell. 21. The gastric lymphomas and the role of Helicobacter pylori in tumour development: have criteria been set for diagnosis? M.F. Dixon. 22. Clinical presentation, diagnosis and treatment of Helicobacter pylori related gastric lymphoma; M. Stolte, et al. 23. Mechanisms of paralysis and apoptosis of the inflammatory cells in Helicobacter pylori infection; K. Deusch. 24. Lessons from the epidemiology of Helicobacter pylori and cancer; J. Parsonnet. 25. H. pylori, acid, gastritis, atrophy and progression to cancer: a critical view; J.W. Freston. 26. Essential co-factors in gastric carcinogenesis; D. Forman. 27. Mechanisms of spread of Helicobacter pylori infection; S.M. Kelly. 28. Whom, how and when to test for Helicobacter pylori infection; A. Axon, et al. 29. Helicobacter pylori infection in children; M. Rowland, B. Drumm.