Harnessing Materials for X-ray Based Cancer Therapy and Imaging

ISBN-13: 9783031040733 / Angielski / Miękka / 2023

Opis

This book discusses the efficacy of nanomaterial-based X-rays enhancers against cancer therapy and imaging in both in vitro and in vivo systems. Also, synthesis, mechanism, and the related biological effects are given. Moreover, nanoparticle-based contrast agents to enhance the image quality are compiled. Finally, special nanoparticle-based contrast agents to enhance the contrast for targeted cancer therapy are covered and discussed.

Spis treści

Chapter 1. Application of X-ray in medicine and X-ray-sensitive materials

 

Hamed RezaeeJam ¹, Fatemeh Abhari ², Surender Kumar Sharma^3,4, Hamed Nosrati⁵

¹Department of Radiology, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.

²Faculty of Medicine, Department of Medical Physics, Tabriz University of Medical

Sciences, Tabriz, Iran.

³Department of Physics, Federal University of Maranhao, Sao Luis, Brazil

⁴Department of Physics, Central University of Punjab, India

⁵Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine, Baku, Azerbaijan

 

Table of Content:

 

1. Introduction

2. Radiotherapy

3. Imaging

4. X-ray-sensitive materials

4.1. Organic materials

4.2. Inorganic materials

4.3. Organic and inorganic hybrid materials

5. Challenges and future scope

 

 

 

 

 

Chapter 2. Radiosensitizers

 

Hossein Rahimi ¹, Hamed Nosrati ^1,2, Surender Kumar Sharma^3,4, Hossein Danafar¹

¹Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45139- 56184, Iran.

²Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine, Baku, Azerbaijan.

³Department of Physics, Federal University of Maranhao, Sao Luis, Brazil

⁴Department of Physics, Central University of Punjab, India

 

Table of Content:

 

1. Introduction

2. Small Molecules

2.1. Oxygen and its Mimics

2.2. Other chemical radiosensitizers

3. Macromolecules

3.1. MicroRNAs

3.2. Proteins and Peptides

3.3. Oligonucleotides and siRNAs

4. Challenges and future scope

 

Chapter 3. Key Parameters in nanoparticles based radiotherapy

 

Céline Frochot ¹, Muriel Barberi-Heyob ², Magali Toussaint²

¹Université de Lorraine, LRGP, UMR 7274, 1 rue Grandville, Nancy, 54000, France

²Université de Lorraine, CRAN, UMR 7039, Campus Sciences, BP 70239, Vandoeuvre-lès-Nancy Cedex, 54506, France

 

Table of Content:

 

1. Introduction

2. Key factors that shoud be measured

2.1. In vitro assessment

3. Biological evaluation methodology

4. The energy of X-rays

5. Irradiation setup

6. Interactions of X-rays with functionalized nanoparticles

7. Challenges and future scope

 

Chapter 4. Nanoradiosensitizers

 

Murat Barsbay, and Mohammadreza Ghaffarlou

Hacettepe University, Department of Chemistry, Beytepe, Ankara 06800, Turkey.

 

Table of Content:

 

1. Introduction

2. Physical aspect

3. Biological aspect

              4. Metal based nanoradiosensitizers

                        4.1 Au based nanoradiosensitizers

4.2. Bi based nanoradiosensitizers

4.3. Other type nanoradiosensitizers

5. Heterostructured nanoradiosensitizers

6. Challenges and conclusion

 

Chapter 5. Nanoparticles for overcome Hypoxia

 

Yaqin Wang^1,2, Wenting Shang²

¹Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China.

²Chinese Academy of Sciences Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China.

 

Table of Content:

 

1. Introduction

2. Targeting hypoxia by nanomedicine

3. Tumor oxygenation by nanomedicine

3.1. Oxygen loaded nanocarriers

3.2. Oxygen generators

4. Hypoxic-active nanoparticles as radiosensitizers

4.1. Nitroimidazoles

4.2. Sanazole

5. Summary and outlook

 

Chapter 6. X-Ray based combination therapy

 

Rovshan Khalilov^1,2, Hamid Rashidzadeh¹

 

¹Department of Biophysics and Molecular Biology, Baku State University, Baku, Azerbaijan

²Russian Institute for Advanced Study, Moscow State Pedagogical University, 1/1, Malaya Pirogovskaya St, Moscow 119991, Russian Federation

 

Table of Content:

 

1. Introduction

2. Combined Chemo-Radiotherapy

3. Combined Immune-Radiotherapy

4. Combined Photo-Radiotherapy

5. Summary and outlook

 

Chapter 7.  X-Ray triggered Photodynamic therapy

 

Ali Mohammadi ¹, Hamed Nosrati ², Surender Kumar Sharma^3,4, Taras Kavetskyy^2,5

¹Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45139- 56184, Iran.

²Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine, Baku, Azerbaijan.

³Department of Physics, Federal University of Maranhao, Sao Luis, Brazil

⁴Department of Physics, Central University of Punjab, India

⁵Department of Surface Engineering, The John Paul II Catholic University of Lublin, 20-950 Lublin, Poland

 

Table of Content:

 

 

1. Introduction

2. X-ray-induced sensitizers

3. Rare-earth-element-based X-ray-induced sensitizers

4. Quantum dot-based X-ray-induced sensitizers

5. Silicon-based X-ray-induced sensitizers

6. Metal-based X-ray-induced sensitizers

7. Challenges

8. Summary and outlook

 

Chapter 8. X-ray tomography contrast agents

 

Mümin Mehmet Koç^1,2, Naim Aslan³

¹School of Engineering, University of Portsmouth, Portsmouth, United Kingdom

²Department of Physics, Kirklareli University, Kirklareli, Turkey

³Department of Metallurgical and Materials Engineering, Munzur University, Tunceli, Turkey.

 

Table of Content:

 

1. Introduction

2. Molecule based contrast agents

2.1. Iodine-based contrast agents

2.2. Phosphotungstic acid

2.3. Phosphomolybdic acid

2.4. Osmium tetroxide

3. Nanoparticle based contrast agents

3.1 Gold nanoparticle based contrast agents

3.2 Silver nanoparticle based contrast agents

3.3. Bi nanoparticle based contrast agents

3.4. Thorium Oxide nanoparticle based contrast agents

3.5. Tantalum nanoparticle based contrast agents

3.6. Rare Earth nanoparticles based contrast agents

4. Summary

 

Chapter 9. Radioprotectors

 

Dmitry Klokov^1,2

¹Laboratory of Radiobiology and Radiotoxicology, Department of Research on Biological and Health Effects of Ionizing Radiation, Institute of Radioprotection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.

²Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

 

Table of Content:

 

1. Introduction

2. Molecular Radioprotectors Delivery by Nanocarriers

2.1. Organic polymeric carriers

2.2. Inorganic carriers

3. Nano Radioprotectors

3.1. Principle

3.2. The Common Nanoradioprotectors

3.2.1. Carbon-Based Nanoradioprotectors

3.2.2. Cerium-Based Nanoradioprotectors

3.2.3. Noble Metal Nanoradioprotectors

4. Summary and outlook

 

Chapter 10. Reactive Oxygen Species (ROS)-Based Radiotherapy: a recent update

 

Andreyan N. Osipov¹, Margarita Pustovalova²

¹State Research Center A. I. Burnazyan Federal Medical Biophysical Center of Federal Medical-Biological Agency of Russia, Moscow, Russia

²State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

 

Table of Content:

 

1. Introduction

2. ROS Chemistry

3. ROS Biology

4. ROS Nanotechnology

5. Future scope and prospective

O autorze

Dr. Sharma is a Faculty Member in Physics at Department of Physics, Central University of Punjab, Bathinda, India. His research interests include magnetic nanohybrids, luminescent nanomaterials, optical properties, nanothermometry, thermal therapy, and bioimaging. 

 

Dr. Nosrati is the International Project Advisor & Developer of Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems (JUAI-REC-NBFN). His research includes the design and synthesis of functional bio-organic and metallic nanoboimaterials for theranostic applications as well as for enhanced chemo and X-ray radiation therapy of cancer.

 

Dr. Kavetskyy is Associate Professor of Chemistry at the Department of Biology and Chemistry and Head of Materials of Solid-State Microelectronics Laboratory of Drohobych Ivan Franko State Pedagogical University, Ukraine, and Adiunkt (Assistant Professor) at the Department of Surface Engineering of The John Paul II Catholic University of Lublin, Poland. He is also Supervisor of Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems in Ukraine and Scientific Secretary of Expert Committee of Scientific Society of The Ministry of Education and Science of Ukraine, Section “Scientific Problems of Materials Science”. His current research interests are glasses, polymers, complex compounds, biomaterials, biosensors, nanosensors, radiation effects, carbon nanostructures, metal nanoparticles, ion implantation, and positron annihilation.