Handbook on Immunosenescence: Basic Understanding and Clinical Applications

ISBN-13: 9781402090622 / Angielski / Twarda / 2009 / 1693 str.

Tamas Fulop; Claudio Franceschi; Katsuiki Hirokawa

Opis

"Immunosenescence" is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?"

Recenzje

From the reviews: "The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections ... . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library." (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)

Spis treści

Methods and Models for Studying Immunosenescence.- The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies.- Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing.- Mouse Models and Genetics of Immunosenescence.- Insect Models of Immunosenescence.- Clonal Culture Models of T-cell Senescence.- Mouse Models of Influenza.- A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction.- Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations.- Cellular Immunosenescene - T Cells.- Age, T-cell Homeostasis, and T-cell Diversity in Humans.- The Role of T-regulatory Cells in Immune Senescence.- Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population.- Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance.- T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance.- Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model.- Activation-Induced Cell Death of T-Cells in Elderly.- CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells.- Generation and Gene Expression of CD28-CD8 T-cells in Human.- Role of Regulatory Subsets During Aging.- Transcription Factors in Mature B-Cells During Aging.- B-Cell Repertoire Changes in Mouse Models of Aging.- B-Cells and Antibodies in Old Humans.- Neutrophil Granulocyte Functions in the Elderly.- Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging.- Synergistic Effects of Ageing and Stress on Neutrophil Function.- Role of Dendritic Cells in Aging.- Phenotypic and Functional Changes of Circulating Monocytes in Elderly.- NK Cells in Human Ageing.- Natural Killer Cells and Human Longevity.- The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity.- Lympho-Hematopoietic Stem Cells and Their Aging.- Implications of Developmental Switches for Hematopoietic Stem Cell Aging.- Associations of Cytokine Polymorphisms with Immunosenescence.- Cytokine Polymorphisms and Immunosenescence.- Role of TLR Polymorphisms in Immunosenescence.- Mechanisms - Receptors and Signal Transduction.- Signal Transduction Changes in T-cells with Aging.- Molecular Signaling of CD95- and TNFR-Mediatedapoptosis in Naïve and Various Memory Subsets of T-Cells.- Mitochondria and Immunosenescence.- Proteasome Activity and Immunosenescence.- Age-Related Changes in Type 1 and Type 2 Cytokine Production in Humans.- Cytokine Expression and Production Changes in Very Old Age.- Neuro-Endocrine-Immune Network and its Age-Related Changes.- Sex Hormones and Immunosenescence.- Glucocorticoids and DHEA: Do They Have a Role in Immunosenescence?.- Thymic Involution and Thymic Renewal.- Inflamm-Aging.- Molecular and Cellular Aspects of Macrophage Aging.- Clinical Relevance in Disease States-Infection.- Aging and HIV Disease: Synergistic Immunological Effects?.- Role of Immunosenescence in Infections and Sepsis in the Elderly.- Beneficial and Detrimental Manifestations of Age on CD8+ T-Cell Memory to Respiratory Pathogens.- HIV Infection as a Model of Accelerated Immunosenescence.- Autoimmunity and Autoimmune Diseases in the Elderly.- Autoimmunity—Aging Mouse Model for Autoimmune Diseases.- Atherosclerosis—An Age-dependent Autoimmune Disease.- Immuno-Inflammatory Athero-Arteriosclerosis Induced by Elastin Peptides. Effect of Age.- Aging, Immunity and Cancer.- Breast Cancer and Immunosenescence.- Aging, Cancer and Apoptosis in Animal Models and Clinical Settings.- Her-2/neu Transgenic Mice for Evaluation of Immune and Antitumor Responses Against Self-Tumor Antigens in the Young and the Old.- Cancer Immunotherapy and Aging: Lessons From the Mouse.- Insulin Resistance, Chronic Inflammation and the Link with Immunosenescence.- Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer’s Disease?.- Inflammatory Markers and Frailty.- CMV Infection and Frailty: Immunologic Consequences and Disease Pathogenesis.- Osteoporosis, Inflammation and Ageing.- Modulation- Nutrition.- Protein-Energy Malnutrition as a Determinant for Immuno-Senescence.- Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Ageing and Longevity.- Immunomoduation by Polyunsaturated Fatty Acids: Impact on T-cell Functions and Signaling.- Omega-3 Polyunsaturated Fatty Acids and Immunosenescence.- Effect of Intrinsic and Extrinsic Lipids on T-cell Signalling.- Effect of Anti-influenza Vaccination on Immune System in the Elderly.- Immunosenescence Modulation by Vaccination.- Interleukin -7 and Immunorejuvenation.- Assessment of Age-related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly.- Thymic Regeneration in Mice and Humans Following Sex Steroid Ablation.- Nutraceuticals and Immune Restoration in the Elderly.- Gene Therapy and Immune Senescence.- Perspectives: Is Immunosenescence Clinically Relevant?.